| Yazarlar |
Doç. Dr. Halit MUĞLU
Türkiye |
Prof. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Nesrin ŞENER
Türkiye |
|
Maesm Ahmed Mohamed Ben Hsin
|
|
Sevil Özkınalı
Türkiye |
Doç. Dr. Osman Emre ÖZKAN
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. İzzet ŞENER
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Some new 1,3,4-thiadiazole compounds derived from 3,4-(methylenedioxy)cinnamic acid were synthesized in this study. Their structures were determined using UV-Vis, IR,1H-NMR, and13C-NMR spectroscopy. Moreover, the antibacterial activities of the new 1,3,4-thiadiazole derivatives were tested against Gram positive (Enterococcus durans, Bacillus subtilis, and Staphylococcus aureus) and gram negative (Salmonella typhimurium, Escherichia coli, Salmonella enteritidis, Salmonella in-fantis, Salmonella kentucky, Enterobacter aerogenes) bacteria using the disk diffusion method. Furthermore, their antifungal activity was tested against Candida albicans using the disk diffusion method. Some of the synthesized compounds (V, VII, XIII, and XIV) showed antibacterial activity against S. aureus. Also, one synthesized compound (VIII) showed antibacterial activity against E. coli, exhibiting 8 and 9 mm inhibition zones using 50 and 80 µL. One compound (IX) showed antibacterial activity against E. aerogenes, exhibiting a 12 mm inhibition zone using 80 µL. One compound (XIII) showed antibacterial activity against S. kentucky, exhibiting an inhibition zone of about 9 mm using 80 µL. Also, one compound (VII) showed antibacterial activity against E. durans, exhibiting 7, 7, and 8 mm inhibition zones using 30, 50, and 80 µL. None of the compounds (I-XV) showed antifungal activity against C. albicans. These results showed that some of the synthesized compounds could be used as antibacterial agents. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazole | Antibacterial activities | Antimicrobial activity | Gram positive | Gram-negative bacteria | IR and NMR spectroscopy |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | LETTERS IN ORGANIC CHEMISTRY |
| Dergi ISSN | 1570-1786 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2019 |
| Cilt No | 16 |
| Sayı | 10 |
| Sayfalar | 825 / 836 |
| Doi Numarası | 10.2174/1570178616666190118153815 |
| Makale Linki | http://dx.doi.org/10.2174/1570178616666190118153815 |
