Synthesis and In-Vitro Antimicrobial Activity of Novel Aminophosphinic Acids Containing Cyclobutane and 1,3-Thiazole
Yazarlar (4)
Prof. Dr. Pelin Koparır Forensic Medicine Institute, Türkiye
Doç. Dr. Muhsin Karaarslan Aksaray Üniversitesi, Türkiye
Öğr. Gör. Dr. Cahit ÖREK Kastamonu Üniversitesi, Türkiye
Prof. Dr. Metin Koparır Fırat Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Phosphorus Sulfur and Silicon and the Related Elements (Q4) | ||
| Dergi ISSN | 1042-6507 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2011 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 31-10-2011 |
| Cilt / Sayı / Sayfa | 186 / 12 / 2368–2376 | DOI | 10.1080/10426507.2011.604660 |
| Makale Linki | http://dx.doi.org/10.1080/10426507.2011.604660 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| The compounds {[4-(3-methyl-3-aryl(mesityl-phenyl-tetralino)cyclobutyl)-1,3-thiazol-2-yl]amino}(aryl)methyl-phosphinic acids 2a–l were prepared by condensation of 2-amino-4-(3-aryl(mesityl-phenyl-tetralino)-3-methylcyclobutyl) thiazoles 1a–c with various aromatic aldehydes and hypophosphorous acid through a one-pot reaction. The characterizations of these compounds were obtained by elemental analyses, infrared (IR) spectra, and 1H, 13C, and 31P NMR (nuclear magnetic resonance) techniques. The synthesized compounds were tested in vitro against one Gram-positive and two Gram-negative bacterial strains, one mycobacterial strain, and a fungus Candida albicans. Compound 2f showed significant activity against Staphylococcus aureus, whereas the others had no remarkable activity on this strain. Compound 2g was found to be more active than the others against Mycobacterium fortuitum at an MIC … |
| Anahtar Kelimeler |
| Aminophosphinic acids | Cyclobutane | Thiazole |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 16 |
| Google Scholar | 29 |