| Yazarlar |
Metin Koparır
Fırat Üniversitesi, Türkiye |
Öğr. Gör. Dr. Cahit ÖREK
Kastamonu Üniversitesi, Türkiye |
|
Akif Evren Parlak
Fırat Üniversitesi, Türkiye |
|
Abdurrazak Söylemez
|
|
Pelin Koparır
|
|
Mustafa Karatepe
Fırat Üniversitesi, Türkiye |
|
Sevgi Durna Daştan
Cumhuriyet Üniversitesi, Türkiye |
| Özet |
| A novel series of compounds were synthesized by cyclic condensation reaction of substituted isothiocyanate (2a-c) with 2-thiophenecarboxylic acid hydrazide (1) in the presence of ethyl alcohol, to obtain intermediate thiosemicarbazides (3a-c), which were further treated with sodium hydroxide in the presence of ethanol to obtain triazole derivatives (4a-c). The latter were refluxed with substituted secondary amines and formaldehyde for 6-10 h to afford Mannich bases (5a-k). The synthesized compounds were characterized on the basis of their spectral (IR, 13C and 1H NMR) data and evaluated for biological activities. Some of the compounds were found to exhibit significant antimicrobial and antioxidant activity. © 2013 Elsevier Masson SAS. All rights reserved. |
| Anahtar Kelimeler |
| 4-Substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones | Biological activity | Mannich bases |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY |
| Dergi ISSN | 0223-5234 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2013 |
| Cilt No | 63 |
| Sayı | 1 |
| Sayfalar | 340 / 346 |
| Doi Numarası | 10.1016/j.ejmech.2013.02.025 |
| Makale Linki | http://dx.doi.org/10.1016/j.ejmech.2013.02.025 |
| Atıf Sayıları | |
| WoS | 65 |
| SCOPUS | 68 |
| Google Scholar | 104 |
