Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones
Yazarlar (7)
Prof. Dr. Metin Koparır Fırat Üniversitesi, Türkiye
Öğr. Gör. Dr. Cahit ÖREK Kastamonu Üniversitesi, Türkiye
Akif Evren Parlak Fırat Üniversitesi, Türkiye
Abdurrazak Söylemez Firat Üniversitesi, Türkiye
Prof. Dr. Pelin Koparır Forensic Medicine Institute, Türkiye
Mustafa Karatepe Fırat Üniversitesi, Türkiye
Sevgi Durna Daştan Cumhuriyet Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | European Journal of Medicinal Chemistry (Q1) | ||
| Dergi ISSN | 0223-5234 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2013 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-05-2013 |
| Cilt / Sayı / Sayfa | 63 / 1 / 340–346 | DOI | 10.1016/j.ejmech.2013.02.025 |
| Makale Linki | http://dx.doi.org/10.1016/j.ejmech.2013.02.025 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| A novel series of compounds were synthesized by cyclic condensation reaction of substituted isothiocyanate (2a–c) with 2-thiophenecarboxylic acid hydrazide (1) in the presence of ethyl alcohol, to obtain intermediate thiosemicarbazides (3a–c), which were further treated with sodium hydroxide in the presence of ethanol to obtain triazole derivatives (4a–c). The latter were refluxed with substituted secondary amines and formaldehyde for 6–10 h to afford Mannich bases (5a–k). The synthesized compounds were characterized on the basis of their spectral (IR, 13C and 1H NMR) data and evaluated for biological activities. Some of the compounds were found to exhibit significant antimicrobial and antioxidant activity. |
| Anahtar Kelimeler |
| 4-Substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones | Biological activity | Mannich bases |
Science Direct
Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 69 |
| Scopus | 72 |
| Google Scholar | 96 |