| Yazarlar |
Taner Daştan
|
|
Ümit Muhammet Koçyiğit
Cumhuriyet Üniversitesi, Türkiye |
|
Sevgi Durna Daştan
Cumhuriyet Üniversitesi, Türkiye |
|
Pakize Cantürk Kılıçkaya
Cumhuriyet Üniversitesi, Türkiye |
|
Parham Taslimi
|
|
Özge Çevik
Adnan Menderes Üniversitesi, Türkiye |
|
Metin Koparır
Fırat Üniversitesi, Türkiye |
Öğr. Gör. Dr. Cahit ÖREK
Kastamonu Üniversitesi, Türkiye |
|
İlhami Gülçin
Atatürk Üniversitesi, Türkiye |
|
Ahmet Çetin
Bingöl Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to evaluate biologically active novel molecules having potentials to be drugs by their antitumor properties and by activities of apoptotic caspase and topoisomerase. Following syntheses of novel eight bis(α-aminoalkyl)phosphinic acid derivatives (4a–h) as a result of array of reactions, compounds were evaluated by cytotoxic effects in vitro on human breast cancer (MCF-7) and normal endothelial (HUVEC) cell lines. All phosphinic acid derivatives were effective for cytotoxicity on both MCF-7 and HUVEC lines, while 4c, 4e, and 4f compounds were found significantly more effective. For the evaluation of antitumor properties of compounds in a highly sensitive method, their effects on inhibiting topoisomerases I and II were investigated. Also, some of the bis(α-aminoalkyl)phosphinic acid derivatives (4a, 4e–h) showed nice inhibitory action against acetylcholinesterase and human carbonic anhydrase isoforms I and II. |
| Anahtar Kelimeler |
| acetylcholinesterase,cytotoxicity,carbonic anhydrase,phosphinic acid,topoisomerase |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Biochemical and Molecular Toxicology |
| Dergi ISSN | 1095-6670 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2017 |
| Cilt No | 31 |
| Sayı | 11 |
| Sayfalar | 21971 / |
| Doi Numarası | 10.1002/jbt.21971 |
| Makale Linki | http://dx.doi.org/10.1002/jbt.21971 |
| Atıf Sayıları | |
| WoS | 36 |
| SCOPUS | 50 |
