Synthesis, structure, cytotoxic and antioxidant properties of 6-ethoxy-4-methylcoumarin
Yazarlar (6)
F. C. Celikezen Bitlis Eren Üniversitesi, Türkiye
Öğr. Gör. Dr. Cahit ÖREK Kastamonu Üniversitesi, Türkiye
A. E. Parlak Firat Üniversitesi, Türkiye
K. Sarac Bitlis Eren Üniversitesi, Türkiye
H. Turkez Erzurum Technical University, Türkiye
Özlem Özdemir Tozlu Erzurum Technical University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Structure (Q3) | ||
| Dergi ISSN | 0022-2860 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2020 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-04-2020 |
| Cilt / Sayı / Sayfa | 1205 / 1 / 127577–0 | DOI | 10.1016/j.molstruc.2019.127577 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0022286019316862 | ||
| UAK Araştırma Alanları |
Genetik
|
||
| Özet |
| Coumarins have a wide usage area in medicinal applications. It is known that the design and synthesis of new coumarin derivatives are performed to prepare new drugs in many laboratories. The aim of the study was to synthesize 6-ethoxy-4-methylcoumarin and detect its chemical and biological properties for the first time. 6-ethoxy-4-methylcoumarin was synthesized using Pechmann method. Atomic orbital (GIAO) 1H and 13C NMR chemical shift values in the ground state were calculated and Density Functional Method (DFT) was applied with the 6–311++G (d, p) basis set to determine chemical properties. 6-ethoxy-4-methylcoumarin was applied to cultured blood samples at various concentrations (10–400 mg/L) for determining biological activity. 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays were used to evaluate cytotoxic effect. In addition … |
| Anahtar Kelimeler |
| Antioxidant | Coumarins | Cytotoxic | DFT | NMR | Vibrational spectra |
Science Direct
Synthesis, structure, cytotoxic and antioxidant properties of 6-ethoxy-4-methylcoumarin
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 16 |
| Google Scholar | 20 |