Experimental and theoretical investigationof antioxidant activity and capacity ofthiosemicarbazones based on isatin derivatives
Yazarlar (3)
Prof. Dr. Temel Kan BAKIR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Hakan Sezgin Sayıner Adiyaman Üniversitesi, Türkiye
Prof. Dr. Fatma Kandemirli Kastamonu Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Phosphorus Sulfur and Silicon and the Related Elements (Q3)
Dergi ISSN 1042-6507 Dergi Bilgileri (2018)
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 04-2018
Kabul Tarihi 11-03-2018 Yayınlanma Tarihi 13-04-2018
Cilt / Sayı / Sayfa 193 / 8 / 493–499 DOI 10.1080/10426507.2018.1452232
Makale Linki https://www.tandfonline.com/doi/full/10.1080/10426507.2018.1452232
UAK Araştırma Alanları
Fiziksel Kimya
Özet
The peroxidation of linoleic acid (LA) in the presence of copper (II) ions alone and with butylhydroxytoluene (BHT), gallic acid (GA), a BHT/GA pair, 5-methoxyisatin-3-(N-4-chlorophenyl) thiosemicarbazone (H25MI3ClPT), and 5-methoxyisatin-3-(N-phenyl) thiosemicarbazone (H25MI3PT) was investigated in aerated and incubated emulsions at 37°C and pH 7. Cu(II)-induced LA peroxidation followed pseudo-first-order kinetics with respect to the primary oxidation products (hydroperoxides), which were determined by the ferric thiocyanate (Fe(III)-SCN) method. It was observed that (H25MI3ClPT) and (H25MI3PT) showed antioxidant properties, but the percentage inhibition decreased as the concentration increased, contrary to the behavior of GA and BHT. In addition, they were investigated by the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method. The IC50 values were 69.60, 11.87, 88.71, 73.62, and 430.11 µM for the standard antioxidants BHT, GA, H25MI3ClPT, H25MI3PT, and bis(isatin-3-(4-iodophenyl)thiosemicarbazonato) zinc(II) (BI3ITZn), respectively. The bond dissociation enthalpy (BDE), adiabatic ionization potential (AIP), proton dissociation enthalpy (PDE), proton affinity (PA), electron transfer enthalpy (ETE), ΔHacidity, ΔGacidity descriptors and DPPH radical scavenging mechanisms of thiosemicarbazone were also determined with the B3LYP method. Furthermore, the energy values in the transition state form for the reactions of H25MI3PT and H25MI3ClPT with DPPH were calculated as 0.022278 and 0.021953 au, respectively.
Anahtar Kelimeler
Antioxidant activity | B3LYP method | DPPH method | ferric thiocyanate method | thiosemicarbazone
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 18
Scopus 21
Experimental and theoretical investigationof antioxidant activity and capacity ofthiosemicarbazones based on isatin derivatives

Paylaş

İletişim
  • Kastamonu Üniversitesi Rektörlüğü, Kuzeykent Kampüsü, Merkez/Kastamonu
  • unis@kastamonu.edu.tr 03662801000
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