Experimental and theoretical investigationof antioxidant activity and capacity ofthiosemicarbazones based on isatin derivatives

BAKIR, Temel Kan; Sayıner, Hakan Sezgin; KANDEMİRLİ, Fatma

doi:10.1080/10426507.2018.1452232

Experimental and theoretical investigationof antioxidant activity and capacity ofthiosemicarbazones based on isatin derivatives

Yazarlar (3)

Prof. Dr. Temel Kan BAKIR Kastamonu Üniversitesi, Türkiye

Prof. Dr. Hakan Sezgin Sayıner Adiyaman Üniversitesi, Türkiye

Prof. Dr. Fatma Kandemirli Kastamonu Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Phosphorus Sulfur and Silicon and the Related Elements
Dergi ISSN	1042-6507 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI
Makale Dili	İngilizce	Basım Tarihi	04-2018
Kabul Tarihi	11-03-2018	Yayınlanma Tarihi	13-04-2018
Cilt / Sayı / Sayfa	193 / 8 / 493–499	DOI	10.1080/10426507.2018.1452232
Makale Linki	https://www.tandfonline.com/doi/full/10.1080/10426507.2018.1452232
UAK Araştırma Alanları	Fiziksel Kimya

Özet

The peroxidation of linoleic acid (LA) in the presence of copper (II) ions alone and with butylhydroxytoluene (BHT), gallic acid (GA), a BHT/GA pair, 5-methoxyisatin-3-(N-4-chlorophenyl) thiosemicarbazone (H25MI3ClPT), and 5-methoxyisatin-3-(N-phenyl) thiosemicarbazone (H25MI3PT) was investigated in aerated and incubated emulsions at 37°C and pH 7. Cu(II)-induced LA peroxidation followed pseudo-first-order kinetics with respect to the primary oxidation products (hydroperoxides), which were determined by the ferric thiocyanate (Fe(III)-SCN) method. It was observed that (H25MI3ClPT) and (H25MI3PT) showed antioxidant properties, but the percentage inhibition decreased as the concentration increased, contrary to the behavior of GA and BHT. In addition, they were investigated by the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging method. The IC50 values were 69.60, 11.87, 88.71, 73.62, and 430.11 µM for the standard antioxidants BHT, GA, H25MI3ClPT, H25MI3PT, and bis(isatin-3-(4-iodophenyl)thiosemicarbazonato) zinc(II) (BI3ITZn), respectively. The bond dissociation enthalpy (BDE), adiabatic ionization potential (AIP), proton dissociation enthalpy (PDE), proton affinity (PA), electron transfer enthalpy (ETE), ΔHacidity, ΔGacidity descriptors and DPPH radical scavenging mechanisms of thiosemicarbazone were also determined with the B3LYP method. Furthermore, the energy values in the transition state form for the reactions of H25MI3PT and H25MI3ClPT with DPPH were calculated as 0.022278 and 0.021953 au, respectively.

Anahtar Kelimeler

Antioxidant activity | B3LYP method | DPPH method | ferric thiocyanate method | thiosemicarbazone

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	16
Scopus	19

Experimental and theoretical investigationof antioxidant activity and capacity ofthiosemicarbazones based on isatin derivatives

Dergi Adı	PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
Yayıncı	Taylor and Francis Ltd.
Açık Erişim	Hayır
ISSN	1042-6507
E-ISSN	1563-5325
CiteScore	2,6
SJR	0,264
SNIP	0,385

Experimental and theoretical investigationof antioxidant activity and capacity ofthiosemicarbazones based on isatin derivatives

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