Studies on Antimicrobial, Antibiofilm, Efflux Pump Inhibiting, and ADMET Properties of Newly Synthesized 1,3,4‐Thiadiazole Derivatives**
Yazarlar (7)
Öğr. Gör. Dr. Merve ZURNACI Kastamonu Üniversitesi, Türkiye
Merve Şenturan
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Prof. Dr. Nesrin ŞENER Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mahmut GÜR Kastamonu Üniversitesi, Türkiye
Eda Altınöz
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Prof. Dr. İzzet ŞENER Kastamonu Üniversitesi, Türkiye
Prof. Dr. Ergin Murat ALTUNER Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Chemistryselect (Q3) | ||
| Dergi ISSN | 2365-6549 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2021 |
| Cilt / Sayı / Sayfa | 6 / 45 / 12571–12581 | DOI | 10.1002/slct.202103214 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202103214 | ||
| UAK Araştırma Alanları |
Organik Kimya
Spektroskopi
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| Özet |
| The novel compounds bearing 1,3,4‐thiadiazole moiety were obtained and their structures were identified using FT‐IR, NMR methods, elemental, and mass analysis. UV‐Vis and fluorescence spectra were obtained in six different polarity solvents. In addition, antimicrobial, antibiofilm, and the efflux pump inhibiting activities of the new compounds on K. pneumoniae, methicillin‐resistant S. aureus (MRSA), E. coli, and C. albicans were investigated. Furthermore, druglikeness and ADMET properties of the compounds were determined. As a result, it was observed that some of the derivatives presented antimicrobial activity against K. pneumoniae, S. aureus, and C. albicans. But the MBC/MFC test showed that all the activities were bacteriostatic. In addition, these derivatives have the potential of using both inhibiting and activating biofilm formation depending on the concentration. 1,3,4‐thiadiazole derivatives also … |
| Anahtar Kelimeler |
| ADMET | antibacterial | antibiofilm | efflux pump inhibition | QSAR |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 6 |
| Google Scholar | 11 |