| Yazarlar |
Prof. Dr. Nesrin ŞENER
Kastamonu Üniversitesi, Türkiye |
Sevil Özkınalı
Türkiye |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Şerife Yerlikaya
Türkiye |
|
Halil Gökce
Türkiye |
Öğr. Gör. Dr. Merve ZURNACI
Kastamonu Üniversitesi, Türkiye |
|
Prof. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Mehmet Cengiz BALOĞLU
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. İzzet ŞENER
Kastamonu Üniversitesi, Türkiye |
| Özet |
| New pyrazole Schiff bases containing azo groups were synthesized using the condensation reaction between p-nitrobenzaldehyde and (E)-4-(phenyl)-1-H-pyrazole-3,5-diamine in the molar ratio of 1:2. Characterization of the compounds was performed by spectroscopic techniques, including IR, UV-Vis, 1H-NMR and 13C-NMR. Biological activity of the compounds was evaluated by analyzing DNA protection, antimicrobial and anticancer properties. Compound 4 was effective for Salmonella typhimurium with the MIC concentration of 62.5 µg/mL. Moreover, this compound had the highest protection activity on DNA. Cytotoxic activity of compound 4 was determined on the HeLa cancer cell line with the IC50 concentration of 976.6 µM. The anti-cancer characteristic of compounds 4 and 5 for HeLa cancer was theoretically analyzed by molecular docking study as well. Among the tested compounds, compound 4 possessed significant results due to its in vitro cytotoxic properties. Therefore, it may be considered as a potential bioactive agent for cancer treatment studies. In addition, further in vivo analysis can be performed to indicate its anticancer property. |
| Anahtar Kelimeler |
| Antimicrobial activity | Azo-Imine | Cytotoxic activity | DNA protection | Molecular docking | Pyrazole | Schiff bases |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Molecular Structure |
| Dergi ISSN | 0022-2860 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 1241 |
| Sayı | 1 |
| Sayfalar | 130520 / 130530 |
| Doi Numarası | 10.1016/j.molstruc.2021.130520 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2021.130520 |
| Atıf Sayıları | |
| SCOPUS | 9 |
| Google Scholar | 12 |
