| Yazarlar |
Doç. Dr. Temel Kan BAKIR
Türkiye |
Mohammed Ali Abraheem Ashweeqı
|
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye |
| Özet |
| In this study, new 1,3,4-thiadiazole-2-amine derivatives containing different substitution groups were synthesized in order to increase the free radical quenching ability of α-lipoic acid. The target thiadiazole amines were derived from thiosemicarbazide reagent. Structural analysis for the synthesized compounds (1–8) was carried out using modern spectroscopic techniques including FTIR, NMR, EIMS spectral analyses. The antioxidant properties of each molecule were elucidated by calculating% inhibition as well as significant IC50 values using the 1,1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging method. The antioxidant activities of the compounds were compared against ascorbic acid, a water-soluble antioxidant, and against α-lipoic acid, the starting molecule of the synthesis step, which actually showed a low DPPH quenching activity. While lipoic acid had a reference standard value of 15,625.02±0.96 µM, compound 8 was the compound with the highest antioxidant activity with an IC50 value of 433.69±0.04 µM. The obtained data suggested that the (N–H) proton in the thiadiazole structure bound to lipoic acid plays an important role in binding to the DPPH radical. This study may provide a source for the synthesis of α-lipoic acid-based thiadiazole derivatives, new compounds with antioxidant properties that can be used in medicine and pharmacy. |
| Anahtar Kelimeler |
| DPPH radical scavenging method | EIMS spectroscopies | FTIR analyses | Thiadiazole | α-Lipoic acid |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Molecular Structure |
| Dergi ISSN | 0022-2860 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2024 |
| Cilt No | 1307 |
| Sayı | 1 |
| Doi Numarası | 10.1016/j.molstruc.2024.137980 |
| Makale Linki | http://dx.doi.org/10.1016/j.molstruc.2024.137980 |
| Atıf Sayıları | |
| SCOPUS | 2 |
