| Yazarlar |
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye |
Hasan Yakan
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Amhimmid Ghayth Amhimmid Misbah
|
Doç. Dr. Muhammet Serdar ÇAVUŞ
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Temel Kan BAKIR
Kastamonu Üniversitesi, Türkiye |
| Özet |
| A series of novel isatin-based Schiff base derivatives, namely β-isatin aldehyde-N,N′-(thio)/carbohydrazone derivatives (1–8), have been synthesized. All of the compounds were purified, and IR, 1H NMR and 13C NMR spectroscopic methods and elemental analysis were used to characterize the compounds. Moreover, the in vitro antioxidant activity of the compounds was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method and compared with standard natural antioxidant, gallic acid. Experimental data were supported by density functional theory (DFT) calculations. B3LYP hybrid functional with 6–311 + + g(2d,2p) basis set was used to calculate ground-state geometries, FMO energies and related chemical reactivity parameters of the compounds. In addition to the structural and spectral analysis calculations of the compounds, NBO, QTAIM, NCI, Fukui and DOS analyses were also performed at the same level of theory, and the data were used to determine the effects of conformational and electronic properties of substitute groups in the reactive regions of the compounds on the reaction with DPPH and to analyze the antioxidant behavior of the compounds. Graphic abstract: New Schiff bases bearing (thio)/carbohydrazone and isatin were synthesized. Structures of synthesized compounds were elucidated using spectroscopic techniques. Antioxidant activities of the compounds were measured by DPPH method. FMO energies, NBO, QTAIM, NCI, Fukui and DOS analyses were used to examine the relationship between the electronic properties and antioxidant activity. [Figure not available: see fulltext.] |
| Anahtar Kelimeler |
| Antioxidant activity | Isatin | Quantum chemical studies | Schiff bases | Spectroscopic techniques |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Research on Chemical Intermediates |
| Dergi ISSN | 1568-5675 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2021 |
| Cilt No | 47 |
| Sayı | 47 |
| Sayfalar | 4985 / 5005 |
| Doi Numarası | 10.1007/s11164-021-04576-7 |
| Makale Linki | https://www.researchgate.net/publication/354203473_Synthesis_structure_characterization_and_quantum_chemical_study_on_relationship_between_structure_and_antioxidant_properties_of_novel_Schiff_bases_bearing_thiocarbohydrazones |
| Atıf Sayıları | |
| SCOPUS | 16 |
