| Yazarlar |
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye |
Mustafa Akın
|
Doç. Dr. Muhammet Serdar ÇAVUŞ
Kastamonu Üniversitesi, Türkiye |
|
Hasan Yakan
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Neslihan Şaki
Türkiye |
|
Emre Güzel
Sakarya Uygulamalı Bilimler Üniversitesi, Türkiye |
| Özet |
| In recent years, compounds containing thiophene and 1,3,4-thiadiazole skeletons have become important cyclic compounds, especially in medicinal chemistry. In this manner, we synthesized and isolated seven 1,3,4-thiadiazole derivatives with thiophene groups and fully characterized by elemental analysis and general spectroscopic methods such as 1H NMR, 13C NMR, and FT-IR. Antibacterial activities of the title compounds were investigated by using TLC-Dot blot, macro dilution, well diffusion, and growth curve analysis methods. Compounds 1 and 6 showed inhibitory activities against all tested gram-negative and gram-positive bacteria. TLC-DPPH and DPPH assays, on the other hand, were performed to detect the antioxidant activities of the 1,3,4-thiadiazole derivatives and compound 1 exhibited the highest antioxidant activity at all tested concentrations. QTAIM and NCI calculations were performed as well as structural, electronic, and spectral analyzes using density functional theory (DFT). Calculations were carried out at the B3lyp/6–311 + +g(2d,2p) level of theory, and the data were used to examine the antioxidant activity of the compounds. |
| Anahtar Kelimeler |
| 1,3,4-thiadiazole | Antibacterial activity | Antioxidant activity | Biochemical assessment | Theoretical investigation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Computational Biology and Chemistry |
| Dergi ISSN | 1476-9271 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2022 |
| Cilt No | 96 |
| Sayı | 107618 |
| Doi Numarası | 10.1016/j.compbiolchem.2021.107618 |
| Makale Linki | http://dx.doi.org/10.1016/j.compbiolchem.2021.107618 |
| Atıf Sayıları | |
| SCOPUS | 23 |
