Exploring of antioxidant and antibacterial properties of novel 1,3,4-thiadiazole derivatives: Facile synthesis, structural elucidation and DFT approach to antioxidant characteristics
Yazarlar (6)
Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye
Mustafa Akın Petroyağ And Kimyasallar San.Tic. A.Ş, Türkiye
Prof. Dr. Muhammet Serdar ÇAVUŞ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Hasan Yakan Ondokuz Mayıs Üniversitesi, Türkiye
Neslihan Şaki Kocaeli Üniversitesi, Türkiye
Prof. Dr. Emre Güzel Sakarya Uygulamalı Bilimler Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Computational Biology and Chemistry (Q2) | ||
| Dergi ISSN | 1476-9271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 96 / 1 / – | DOI | 10.1016/j.compbiolchem.2021.107618 |
| Makale Linki | http://dx.doi.org/10.1016/j.compbiolchem.2021.107618 | ||
| Özet |
| In recent years, compounds containing thiophene and 1,3,4-thiadiazole skeletons have become important cyclic compounds, especially in medicinal chemistry. In this manner, we synthesized and isolated seven 1,3,4-thiadiazole derivatives with thiophene groups and fully characterized by elemental analysis and general spectroscopic methods such as 1H NMR, 13C NMR, and FT-IR. Antibacterial activities of the title compounds were investigated by using TLC-Dot blot, macro dilution, well diffusion, and growth curve analysis methods. Compounds 1 and 6 showed inhibitory activities against all tested gram-negative and gram-positive bacteria. TLC-DPPH and DPPH assays, on the other hand, were performed to detect the antioxidant activities of the 1,3,4-thiadiazole derivatives and compound 1 exhibited the highest antioxidant activity at all tested concentrations. QTAIM and NCI calculations were performed as well as structural, electronic, and spectral analyzes using density functional theory (DFT). Calculations were carried out at the B3lyp/6–311 + +g(2d,2p) level of theory, and the data were used to examine the antioxidant activity of the compounds. |
| Anahtar Kelimeler |
| 1,3,4-thiadiazole | Antibacterial activity | Antioxidant activity | Biochemical assessment | Theoretical investigation |
Science Direct
Exploring of antioxidant and antibacterial properties of novel 1,3,4-thiadiazole derivatives: Facile synthesis, structural elucidation and DFT approach to antioxidant characteristics
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 44 |