1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
 
Yazarlar (6)
Ümit M. Koçyiğit
Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Parham Taslımı Bartin Üniversitesi, Türkiye
Prof. Dr. Burak Tüzün Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Hasan Yakan Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Emre Güzel Sakarya University Of Applied Sciences, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Journal of Biomolecular Structure and Dynamics (Q1)
Dergi ISSN 0739-1102 Dergi Bilgileri (2022)
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili Türkçe Basım Tarihi 05-2022
Kabul Tarihi 25-11-2020 Yayınlanma Tarihi 09-12-2020
Cilt / Sayı / Sayfa 40 / 10 / 4429–4439 DOI 10.1080/07391102.2020.1857842
Makale Linki http://dx.doi.org/10.1080/07391102.2020.1857842
UAK Araştırma Alanları
Organik Kimya
Özet
In recent years, acetylcholinesterase (AChE) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, cancer, and Alzheimer's. In this manner, the preparation and enzyme inhibition activities of peripherally 1,2,3-triazole group substituted metallophthalocyanine derivatives with strong absorption in the visible region were presented. These novel metallophthalocyanine derivatives (2-6) effectively inhibited AChE, with Ki values in the range of 40.11 ± 5.61 to 78.27 ± 15.42 µM. For α-glycosidase, the most effective Ki values of compounds 1 and 2 were with Ki values of 16.11 ± 3.13 and 18.31 ± 2.42 µM, respectively. Also, theoretical calculations were investigated to compare the chemical and biological activities of the ligand (1) and its metal complexes (2–6). Biological activities of 1 and its complexes against acetylcholinesterase for ID 4M0E (AChE) and α-glycosidase for ID 1R47 (α-gly) are calculated. Theoretical calculations were compatible with the experimental results and these 1,2,3-triazole substituted phthalocyanine metal complexes were found to be efficient inhibitors for anticholinesterase and antidiabetic enzymes. Communicated by Ramaswamy H. Sarma.
Anahtar Kelimeler
DFT studies | enzyme inhibition | molecular docking | Phthalocyanine | triazole
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Scopus 39
1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies

Paylaş

İletişim
  • Kastamonu Üniversitesi Rektörlüğü, Kuzeykent Kampüsü, Merkez/Kastamonu
  • unis@kastamonu.edu.tr 03662801000
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