| Yazarlar |
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye |
Hasan Yakan
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Hanan A Almabrok Shouaib
|
| Özet |
| Novel 1,3,4-thiadiazole derivatives were prepared by cyclization reaction of thiophene-2-carboxylic acid with N-arylthiosemicarbazides and POCl3. The antibacterial activities of the synthesized compounds were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli), Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans), and the fungus Candida albicans using the disk diffusion method. Selected 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, C. albicans, S. typhimurium, E. aerogenes, and S. kentucky. Therefore, 1,3,4-thiadiazole derivatives can be considered as bioactive agents for pharmacological and medicinal applications. The synthesized compounds were characterized by using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazoles | Antimicrobial activity | N-arylthiosemicarbazides | Spectroscopic methods | Thiophene-2-carboxylic acid |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Molecular Structure |
| Dergi ISSN | 0022-2860 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2020 |
| Cilt No | 1203 |
| Sayı | 1203 |
| Doi Numarası | 10.1016/j.molstruc.2019.127470 |
| Makale Linki | https://ui.adsabs.harvard.edu/abs/2020JMoSt120327470M/abstract |
| Atıf Sayıları | |
| SCOPUS | 26 |
