Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4-Thiadiazole Moiety and Their Antimicrobial Activities

GÜR, Mahmut; ŞENER, Nesrin; Kaştaş, Çiğdem A.; ÖZKAN, Osman Emre; MUĞLU, Halit; Elmaswari, Magboule A.M.

doi:10.1002/jhet.2984

Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4-Thiadiazole Moiety and Their Antimicrobial Activities

Yazarlar (6)

Prof. Dr. Mahmut GÜR Kastamonu Üniversitesi, Türkiye

Prof. Dr. Nesrin ŞENER Kastamonu Üniversitesi, Türkiye

Çiğdem A. Kaştaş Ondokuz Mayis Üniversitesi, Türkiye

Doç. Dr. Osman Emre ÖZKAN Kastamonu Üniversitesi, Türkiye

Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye

Magboule A.M. Elmaswari
Kastamonu Üniversitesi, Türkiye

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	Journal of Heterocyclic Chemistry
Dergi ISSN	0022-152X Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI
Makale Dili	İngilizce	Basım Tarihi	09-2017
Cilt / Sayı / Sayfa	54 / 6 / 3578–3590	DOI	10.1002/jhet.2984
Makale Linki	https://dbs.yok.gov.tr/menu/menu.zul

Özet

Through a cyclization reaction of 2-phenylbutyric acid with N-phenylthiosemicarbazide and POCl3, novel 1,3,4-thiadiazole derivatives were synthesized. Their structures were confirmed using IR, ¹H NMR, and ¹³C NMR spectroscopies and elemental analysis. The antibacterial activities of the obtained 1,3,4-thiadiazole derivatives were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans) using a disk diffusion method. Moreover, an antifungal activity experiment was performed against Candida albicans using the disk diffusion method. It was observed that the synthesized 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, E. coli, and C. albicans. Based on these results, the 1,3,4-thiadiazole derivatives can be considered as a source of bioactive agents for pharmacological and medicinal applications.

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Atıf Sayıları
Scopus	20

Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4-Thiadiazole Moiety and Their Antimicrobial Activities

Dergi Adı	JOURNAL OF HETEROCYCLIC CHEMISTRY
Yayıncı	John Wiley and Sons Inc
Açık Erişim	Hayır
ISSN	0022-152X
E-ISSN	1943-5193
CiteScore	4,7
SJR	0,362
SNIP	0,644

Synthesis and Characterization of Some New Heteroaromatic Compounds Having Chirality Adjacent to a 1,3,4-Thiadiazole Moiety and Their Antimicrobial Activities

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