Synthesis and Characterization of Some New 1,3,4-thiadiazole Compounds Derived from 3,4-(methylenedioxy)cinnamic acid and their antimicrobial activities
Yazarlar (7)
Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mahmut GÜR Kastamonu Üniversitesi, Türkiye
Maesm Ahmed Mohamed Ben Hsin Kastamonu Üniversitesi, Türkiye
Prof. Dr. Nesrin ŞENER Kastamonu Üniversitesi, Türkiye
Prof. Dr. Sevil Özkınalı Hitit Üniversitesi, Türkiye
Doç. Dr. Osman Emre ÖZKAN Kastamonu Üniversitesi, Türkiye
Prof. Dr. İzzet ŞENER Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Letters in Organic Chemistry (Q4) | ||
| Dergi ISSN | 1570-1786 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 16 / 10 / 825–836 | DOI | 10.2174/1570178616666190118153815 |
| Makale Linki | https://www.researchgate.net/publication/331475942_Synthesis_and_Characterization_of_Some_New_134-thiadiazole_Compounds_Derived_from_34-Methylenedioxycinnamic_Acid_and_their_Antimicrobial_Activities | ||
| Özet |
| Some new 1,3,4-thiadiazole compounds derived from 3,4-(methylenedioxy)cinnamic acid were synthesized in this study. Their structures were determined using UV-Vis, IR,1H-NMR, and13C-NMR spectroscopy. Moreover, the antibacterial activities of the new 1,3,4-thiadiazole derivatives were tested against Gram positive (Enterococcus durans, Bacillus subtilis, and Staphylococcus aureus) and gram negative (Salmonella typhimurium, Escherichia coli, Salmonella enteritidis, Salmonella in-fantis, Salmonella kentucky, Enterobacter aerogenes) bacteria using the disk diffusion method. Furthermore, their antifungal activity was tested against Candida albicans using the disk diffusion method. Some of the synthesized compounds (V, VII, XIII, and XIV) showed antibacterial activity against S. aureus. Also, one synthesized compound (VIII) showed antibacterial activity against E. coli, exhibiting 8 and 9 mm inhibition zones using 50 and 80 µL. One compound (IX) showed antibacterial activity against E. aerogenes, exhibiting a 12 mm inhibition zone using 80 µL. One compound (XIII) showed antibacterial activity against S. kentucky, exhibiting an inhibition zone of about 9 mm using 80 µL. Also, one compound (VII) showed antibacterial activity against E. durans, exhibiting 7, 7, and 8 mm inhibition zones using 30, 50, and 80 µL. None of the compounds (I-XV) showed antifungal activity against C. albicans. These results showed that some of the synthesized compounds could be used as antibacterial agents. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazole | Antibacterial activities | Antimicrobial activity | Gram positive | Gram-negative bacteria | IR and NMR spectroscopy |
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