| Yazarlar |
Doç. Dr. Nesrin İÇLİ
Kastamonu Üniversitesi, Türkiye |
Zeliha Kayaaltı
Türkiye |
|
Tülin Söylemezoğlu
Yakın Doğu Üniversitesi, Türkiye |
| Özet |
| Coke-oven workers are occupationally exposed to high concentrations of polycyclic aromatic hydrocarbons. In this study, 1-hydroxypyrene, 9-hydroxyphenantrene, and 3-hydroxybenzo[a]pyrene levels were determined in the urine of occupationally exposed coke-oven worker as markers of exposure to polycyclic aromatic hydrocarbons. The validated high-pressure liquid chromatography method with fluorescence detection was performed for metabolite analysis. Average values of 1-hydroxypyrene were 1.26 µmol/mol creatinine and of 9-hydroxyphenantrene 3.68 µmol/mol creatinine in the workers group, and 0.04 and 0.06 µmol/mol creatinine in the control group. While the average value of 3-hydroxybenzo[a]pyrene was 0.007 µmol/mol creatinine in the workers group, it was below the limit of detection in the control group. All of the mean 1-hydroxypyrene values (coke-oven workers overall mean = 1.26 μmol/mol creatinine; high exposure group mean = 1.91 μmol/mol creatinine; low exposure group mean = 0.66 μmol/mol creatinine) obtained in the workers group were higher than the biological exposure index (0.5 μmol/mol creatinine) that warrants occupational exposure proposed by American Conference of Government Industrial Hygienists. Urinary 1-hydroxypyrene mean levels of all coke-oven workers and the high exposure group exceeded the no observed genotoxic effect level of 1 μmol/mol creatinine. |
| Anahtar Kelimeler |
| biomonitoring | occupational exposure | PAH metabolites | risk assessment | toxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY |
| Dergi ISSN | 0277-2248 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 02-2021 |
| Cilt No | 103 |
| Sayı | 2 |
| Sayfalar | 219 / 235 |
| Doi Numarası | 10.1080/02772248.2021.1945603 |
| Makale Linki | http://dx.doi.org/10.1080/02772248.2021.1945603 |
| Atıf Sayıları |
