Response of thymus lymphocytes to streptozotocin induced diabetes and exogenous vitamin C administration in rats
Yazarlar (3)
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Nesrin Ozsoy Ankara Üniversitesi, Türkiye
Prof. Dr. Suna Cebesoy Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Microscopy (Q3) | ||
| Dergi ISSN | 2050-5698 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2014 |
| Cilt / Sayı / Sayfa | 63 / 6 / 409–417 | DOI | 10.1093/jmicro/dfu029 |
| Makale Linki | http://jmicro.oxfordjournals.org/cgi/doi/10.1093/jmicro/dfu029 | ||
| Özet |
| Diabetes causes oxidative stress, which in turn generates excessive free radicals resulting in cellular damage. Vitamin C is an antioxidant that protects tissues and organs from oxidative stress. The thymus is one of the most important lymphoid organs, which regulates T-lymphocyte proliferation and maturation. The aim of this study is to investigate the protective effects of vitamin C on the thymus of streptozotocin (STZ)-induced diabetic rats. The mitotic activity and cell integrity of thymic lymphocytes were explored. Wistar Albino rats were divided into three groups: control (Group 1), STZ-diabetes (Group 2) and vitamin C-treated STZ-diabetics (Group 3). Rats received a single intraperitoneal injection of 45 mg/kg STZ to induce diabetes. Vitamin C (20 mg/kg) was administered intragastrically. Semithin and ultrathin sections were examined under a light or an electron microscope, respectively. Considerable numbers of … |
| Anahtar Kelimeler |
| Diabetes | Electron microscope | Mitotic activity | Thymus | Vitamin C |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 8 |