Protective effects of cytokine combinations against the apoptotic activity of glucocorticoids on CD34(+) hematopoietic stem/progenitor cells
Yazarlar (4)
Serap Erdem Kuruca İstanbul Tıp Fakültesi, Türkiye
Muzaffer Beyza Çetin
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty Of Medicine, Türkiye
Kadriye Akgün Dar
Istanbul Üniversitesi, Türkiye
Istanbul Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Cytotechnology (Q4) | ||
| Dergi ISSN | 0920-9069 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Cilt / Sayı / Sayfa | 71 / 1 / 67–77 | DOI | 10.1007/s10616-018-0265-x |
| Makale Linki | https://link.springer.com/article/10.1007/s10616-018-0265-x | ||
| Özet |
| Haematopoietic stem cells can self-renew and produce progenitor cells, which have a high proliferation capacity. Chemotherapeutic drugs are toxic to normal cells as well as cancer cells, and glucocorticoids (GCs), which are essential drugs for many chemotherapeutic protocols, efficiently induce apoptosis not only in malignant cells but also in normal haematopoietic cells. Studies have shown that haematopoietic cytokines can prevent the apoptosis induced by chemotherapy and decrease the toxic effects of these drugs. However, the apoptosis induction mechanism of GCs in CD34+ haematopoietic cells and the anti-apoptotic effects of cytokines have not been well elucidated. In this study, we investigated the apoptotic effects of GCs on CD34+, a haematopoietic stem/progenitor cell (HSPC) population, and demonstrated the protective effects of haematopoietic cytokines. We used a cytokine cocktail containing early … |
| Anahtar Kelimeler |
| Apoptosis | CD34 + haematopoietic stem/progenitor cells | Cytokines | Glucocorticoids |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 3 |