Vitamin D and melatonin protect the cell's viability and ameliorate the CCl4 induced cytotoxicity in HepG2 and Hep3B hepatoma cell lines
Yazarlar (3)
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Nesrin Özsoy
Ankara Üniversitesi, Türkiye
Ankara Üniversitesi, Türkiye
Erkan Yılmaz Ankara Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Cytotechnology (Q3) | ||
| Dergi ISSN | 0920-9069 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2015 |
| Cilt / Sayı / Sayfa | 67 / 6 / 995–1002 | DOI | 10.1007/s10616-014-9738-8 |
| Makale Linki | https://link.springer.com/article/10.1007/s10616-014-9738-8 | ||
| Özet |
| Carbon tetrachloride (CCl4) is widely used to induce liver toxicity in in vitro/in vivo models. Lipid peroxidation (LPO) begins with toxicity and affects cell viability. Recently, the beneficial effects of melatonin and Vitamin D on cell proliferation in human normal and cancer cells were found. This study was planned to evaluate antioxidant and cytoprotective activity of melatonin and Vitamin D in CCl4 induced cytotoxicity in HepG2 and Hep3B hepatoma cell lines. Based on the cytotoxicity assay, melatonin and Vitamin D were evaluated for cytotoprotective potential against CCl4 induced toxicity in HepG2 and Hep3B liver cell lines by monitoring cell viability, LPO and glutathione (GSH) level. Different dosages of CCl4 (0.1, 0.2, 0.3 and 0.4 % v/v) were applied to HepG2 and Hep3B cells in order to determine the most toxic dosage of it in a time dependent manner. The same experiments were repeated with exogenously … |
| Anahtar Kelimeler |
| CCl4 | Cell proliferation | Hep3B | HepG2 | Liver cytotoxicity | Melatonin | Vitamin D |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 17 |
| Google Scholar | 30 |