The protective effect of vitamin D against carbon tetrachloride damage to the rat liver.
Yazarlar (5)
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
N. Özsoy Ankara Üniversitesi, Türkiye
K. G. Akbulut Gazi Üniversitesi, Türkiye
Güney Gazi Üniversitesi, Türkiye
G. Öztürk Istanbul Medeniyet University, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnic and Histochemistry (Q4) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2017 |
| Cilt / Sayı / Sayfa | 92 / 7 / 513–523 | DOI | 10.1080/10520295.2017.1361549 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/10520295.2017.1361549 | ||
| Özet |
| We investigated the protective effect of vitamin D against liver damage caused by carbon tetrachloride (CCl4). Twenty-four male rats were divided into four equal groups: G1, untreated controls; G2, administered CCl4; G3, administered both CCl4 and vitamin D for 10 weeks; G4, administered CCl4 for 10 weeks and vitamin D for 12 weeks. At the end of experiment, intracardiac blood samples were taken and liver samples were removed. Hepatic damage due to CCl4 was assessed using biochemistry and histopathology. Glutathione (GSH) levels decreased, while malondialdehyde (MDA) levels increased in liver tissues of G2. Alanine transaminase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl-transaminase (GGT) levels increased, while albumin (ALB) levels decreased. Hepatocyte degeneration, lobular disorder, sinusoid dilation, focal necrotic areas, hyperemia, and glycogen loss were observed … |
| Anahtar Kelimeler |
| carbon tetrachloride | desmin | hepatic fibrosis | matrix metalloproteinase-9 | oxidative stress | vitamin D |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 16 |
| Google Scholar | 22 |