Novel palladium (II) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, in vitro cytotoxicity and xanthine oxidase inhibition.
Yazarlar (6)
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Onur Ertik Istanbul University-Cerrahpasa, Türkiye
Buşra Kaya Istanbul University-Cerrahpasa, Türkiye
Serap Erdem Kuruca İstanbul Tıp Fakültesi, Türkiye
Prof. Dr. Refiye Yanardag Istanbul University-Cerrahpasa, Türkiye
Bahri Ülküseven Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Investigational New Drugs (Q2) | ||
| Dergi ISSN | 0167-6997 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2019 |
| Cilt / Sayı / Sayfa | 37 / 6 / 1187–1197 | DOI | 10.1007/s10637-019-00751-1 |
| Makale Linki | https://link.springer.com/article/10.1007/s10637-019-00751-1 | ||
| Özet |
| In vitro cytotoxicity and xanthine oxidase inhibition capabilities were investigated for five palladium (II) chelate complexes. The palladium complexes were synthesized by starting from S-alkyl-thiosemicarbazones where the alkyl component is methyl, ethyl, propyl or butyl. The solid complexes are characterized by elemental analysis and spectroscopic techniques (UV-visible, IR and 1H NMR). In order to be able to verify the N2O2-type thiosemicarbazidato ligand (L2−) structure in the square planar geometry, complex 1 has been studied as a representative by using single crystal X-ray crystallography. The in vitro cytotoxic activity measurements were carried out in HepG2 and Hep3B hepatocellular carcinomas, HCT116 colorectal carcinoma, and 3 T3 mouse fibroblast cell lines. The palladium complexes exhibited notable cytotoxic activities in all cell lines at lower μM concentrations compared to the standard … |
| Anahtar Kelimeler |
| Cytotoxicity | Palladium | Thiosemicarbazone | X-ray analysis | Xanthine oxidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 31 |
| Scopus | 38 |
| Google Scholar | 46 |