Novel palladium (II) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, in vitro cytotoxicity and xanthine oxidase inhibition.
Yazarlar (6)
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Onur Ertik Istanbul University-Cerrahpasa, Türkiye
Arş. Gör. Buşra Kaya Istanbul University-Cerrahpasa, Türkiye
Serap Erdem Kuruca
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Prof. Dr. Refiye Yanardag Istanbul University-Cerrahpasa, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Investigational New Drugs (Q2) | ||
| Dergi ISSN | 0167-6997 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2019 |
| Cilt / Sayı / Sayfa | 37 / 6 / 1187–1197 | DOI | 10.1007/s10637-019-00751-1 |
| Makale Linki | https://link.springer.com/article/10.1007/s10637-019-00751-1 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| In vitro cytotoxicity and xanthine oxidase inhibition capabilities were investigated for five palladium (II) chelate complexes. The palladium complexes were synthesized by starting from S-alkyl-thiosemicarbazones where the alkyl component is methyl, ethyl, propyl or butyl. The solid complexes are characterized by elemental analysis and spectroscopic techniques (UV-visible, IR and 1H NMR). In order to be able to verify the N2O2-type thiosemicarbazidato ligand (L2−) structure in the square planar geometry, complex 1 has been studied as a representative by using single crystal X-ray crystallography. The in vitro cytotoxic activity measurements were carried out in HepG2 and Hep3B hepatocellular carcinomas, HCT116 colorectal carcinoma, and 3 T3 mouse fibroblast cell lines. The palladium complexes exhibited notable cytotoxic activities in all cell lines at lower μM concentrations compared to the standard … |
| Anahtar Kelimeler |
| Cytotoxicity | Palladium | Thiosemicarbazone | X-ray analysis | Xanthine oxidase |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 31 |
| Scopus | 38 |
| Google Scholar | 46 |