| Yazarlar |
Cevriye Kalkandelen
İstanbul Üniversitesi-Cerrahpaşa, Türkiye |
|
Songül Ulağ
|
|
Burak Özbek
|
|
Güneş O Eroğlu
|
Doç. Dr. Dilşad ÖZERKAN
İstinye Üniversitesi, Türkiye |
|
Dürdane Serap Kuruca
İstanbul Üniversitesi, Türkiye |
|
Faik Nüzhet Oktar
Marmara Üniversitesi, Türkiye |
|
Mustafa Şengör
|
|
Oğuzhan Gündüz
Marmara Üniversitesi, Türkiye |
| Özet |
| Bone tissue engineering studies have brought three-dimensional scaffolds into focus that can provide tissue regeneration with designed porosity and strengthened structure. Current research has concentrated on the fabrication of natural and synthetic polymer-based complex structures that closely mimic biological tissues due to their superior biocompatibility and biodegradabilities. Gelatine/Sodium Alginate hydrogels reinforced with different concentrations of β-Tricalcium Phosphate (TCP) (10, 13, and 15 wt.%) were studied to form 3D bone tissue. Physical, mechanical, chemical, morphological properties and biodegradability of the constructs were investigated. Furthermore, in vitro biological assay with human osteosarcoma cell line (SAOS-2) was performed to determine the biocompatibility of the constructs. It is found that cell viability rates for all constructs were increased and maximum cell viability rate was attained for 20%Gelatine/2%Alginate/10%TCP (wt.). The present work demonstrates that 3D printed Gelatine/Alginate/TCP constructs with porous structures are potential candidates for bone tissue engineering applications. |
| Anahtar Kelimeler |
| Alginate,Gelatine,beta-tricalcium phosphate,3D printing |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ChemistrySelect |
| Dergi ISSN | 2365-6549 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2019 |
| Cilt No | 4 |
| Sayı | 41 |
| Sayfalar | 12032 / 12036 |
| Doi Numarası | 10.1002/slct.201902878 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201902878 |
| Atıf Sayıları | |
| WoS | 12 |
| SCOPUS | 14 |
