Some Bryophytes Trigger Cytotoxicity of Stem Cell-like Population in 5-Fluorouracil Resistant Colon Cancer Cells
Yazarlar (5)
Doç. Dr. Dilşad ÖZERKAN İstinye Üniversitesi, Türkiye
Öğr. Gör. Ayşe Erol İstanbul Üniversitesi, Türkiye
Prof. Dr. Ergin Murat ALTUNER Kastamonu Üniversitesi, Türkiye
Prof. Dr. Kerem Canlı Dokuz Eylül Üniversitesi, Türkiye
Prof. Dr. Dürdane Serap Kuruca İstanbul Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Nutrition and Cancer (Q3) | ||
| Dergi ISSN | 0163-5581 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2022 |
| Cilt / Sayı / Sayfa | 74 / 3 / 1012–1022 | DOI | 10.1080/01635581.2021.1933098 |
| Makale Linki | http://dx.doi.org/10.1080/01635581.2021.1933098 | ||
| Özet |
| Colorectal cancer is the third most common cancer worldwide. Cancer stem cells are known to play an important role in relapse, and metastases of the disease after chemotherapy. Investigation of new drugs, and their combinations targeting these cells and thus eliminating cancer is one of the most urgent needs of today’s chemotherapy. The aim of the present study was to evaluate the effects of Bryophytes like Abietinella abietina (AA), Homolothecium sericeum (HS), Tortella tortuosa (TT), Syntrichia ruralis (SR), and Bryoerythrophyllum rubrum (BR) species extracted with ethyl alcohol on 5-fluorouracil(5-FU) resistant colorectal cancer cell lines (HCT116 and HT29). After extraction, stock solutions of bryophytes were prepared, and IC50 values were detected in drug-resistant cells obtained with 5-FU application. CD24+, CD44+/CD133+ surface markers and P‐glycoprotein (P-gp) mediated efflux were isolated from … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 7 |
| Google Scholar | 10 |