| Yazarlar |
Hakan Sezgin Sayiner
Türkiye |
|
Mehmet Yılmazer
Türkiye |
|
Aisha. T. Abdelsalam
|
|
Mohamed A. Ganim
|
|
Mehmet Cengiz Kayacan
Türkiye |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
|
Murat Saraçoğlu
Erciyes Üniversitesi, Türkiye |
|
Mohamed S. Attia
|
|
Safwat A. Mahmoud
|
|
Ekram H. Mohamed
|
|
Rabah Boukherroub,
|
|
Sarah Alharthi
|
|
Nora Hamad Al- Shaalan
|
Prof. Dr. Fatma KANDEMİRLİ
Kastamonu Üniversitesi, Türkiye |
|
Mohammed A. Amin
|
| Özet |
| 1,3,4-Thiadiazole molecules (1-4) were synthesized by the reaction of phenylthiosemicarbazide and methoxy cinnamic acid molecules in the presence of phosphorus oxychloride, and characterized with UV, FT-IR, 13C-NMR, and 1H-NMR methods. DFT calculations (b3lyp/6-311++G(d,p)) were performed to investigate the structures' geometry and physiochemical properties. Their antibacterial activity was screened for various bacteria strains such as Enterobacter aerogenes, Escherichia coli ATCC 13048, Salmonella kentucky, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus and Gram positive such as Staphylococcus aureus ATCC 25923, Listeria monocytogenes ATCC 7644, Enterococcus faecium, Enterococcus durans, Staphylococcus aureus ATCC, Serratia marcescens, Staphylococcus hominis, Staphylococcus epidermidis, alfa Streptococcus haemolyticus, Enterococcus faecium and found to have an inhibitory effect on Klebsiella pneumoniae and Staphylococcus hominis, while molecules 1, 3 and 4 had an inhibitory effect on Staphylococcus epidermidis and alpha Streptococcus haemolyticus. The experimental results were supported by the docking study using the Kinase ThiM from Klebsiella pneumoniae. All the investigated compounds showed an inhibitory effect for the Staphylococcus epidermidis protein. In addition, the mechanism of the 1-4 molecule interaction with calf thymus-DNA (CT-DNA) was investigated by UV-vis spectroscopic methods. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | RSC Advances |
| Dergi ISSN | 2046-2069 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2022 |
| Cilt No | 12 |
| Doi Numarası | 10.1039/d2ra02435g |
| Makale Linki | http://dx.doi.org/10.1039/d2ra02435g |
