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Theoretical study of the adsorption of BMSF-BENZ drug for osteoporosis disease treatment on Al-doped carbon nanotubes (Al-CNT) as a drug delivery vehicle   
Yazarlar (3)
Zaid Husham Al-Sawaff
Serap Şentürk Dalgıç
Türkiye
Prof. Dr. Fatma KANDEMİRLİ Prof. Dr. Fatma KANDEMİRLİ
Kastamonu Üniversitesi, Türkiye
Devamını Göster
Özet
Osteoporosis is a disease characterized by low bone mass and the microarchitectural deterioration of bone tissue, leading to bone fragility and increased fracture risk [1]. Most of the therapies used for the treatment of osteoporosis inhibit bone resorption and prevent further bone loss. However, as many osteoporosis patients already lost a large amount of bone at their diagnosis, agents need agents to stimulate new bone formation [2].This approach’s drug and enhancements’ discovery goal is to identify a CaSR-antagonist, that is, rapidly absorbed (short Tmax) and fairly rapidly eliminated. Based on its overall in vitro and physicochemical properties, one of the BMSF-BENZ derivatives ((4-Bromo-7-methoxy-1-(2-methoxyethyl)-5-{[3-(methylsulfonyl) phenyl] methyl}-2-[4-(propane-2-yl) phenyl]-1H-1, 3-benzothiazole)(Figure 1) was selected because it showed a sharp PTH-release peak and good properties regarding CaSR receptor [3]. With the increasing development of
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü Uluslararası alan indekslerindeki dergilerde yayınlanan tam makale
Dergi Adı European Journal of Chemistry
Dergi ISSN 2153-2249
Dergi Tarandığı Indeksler WorldCat, Index Copernicus
Makale Dili Türkçe
Basım Tarihi 01-2021
Makale Linki www.eurjchem.com
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Google Scholar 23

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