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Synthesis and characterization of novel hydrazide hydrazones and the study of their structure antituberculosis activity    
Yazarlar (7)
Bedia Koçyiğit-Kaymakçıoğlu
Oruç Elçin
Seda Unsalan
Prof. Dr. Fatma KANDEMİRLİ Prof. Dr. Fatma KANDEMİRLİ
Kocaeli Üniversitesi, Türkiye
Nathaly Shvets
Sevim Rollas
Dimoglo Anatholy
Devamını Göster
Özet
A series of hydrazide–hydrazones, based on a series of 4-substituted benzoic acid, were synthesized, and their structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv with the help of the BACTEC 460 radiometric system. Compound 3, 4-fluorobenzoic acid [((5-nitro)thiophen-2yl) methylene]hydrazide showed the highest inhibitory activity in this series. The search of pharmacophores was done by means of the Electronic-Topological Method (ETM). The model developed in this study is supposed to be applied to the design, preparation and screening of new compounds of similar structure in order to further test and optimize the model with the eventual goal of preparing new anti-tubercular agents.
Anahtar Kelimeler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı DRUGS OF THE FUTURE
Dergi ISSN 0377-8282 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 07-2007
Cilt No 32
Sayı 11
Sayfalar 123 / 124
Doi Numarası 10.1016/j.ejmech.2006.06.009
Makale Linki http://linkinghub.elsevier.com/retrieve/pii/S0223523406002339