| Yazarlar (7) |
Bedia Koçyiğit-Kaymakçıoğlu
|
|
Oruç Elçin
|
|
Seda Unsalan
|
Prof. Dr. Fatma KANDEMİRLİ
Kocaeli Üniversitesi, Türkiye |
|
Nathaly Shvets
|
|
Sevim Rollas
|
|
Dimoglo Anatholy
|
| Özet |
| A series of hydrazide–hydrazones, based on a series of 4-substituted benzoic acid, were synthesized, and their structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv with the help of the BACTEC 460 radiometric system. Compound 3, 4-fluorobenzoic acid [((5-nitro)thiophen-2yl) methylene]hydrazide showed the highest inhibitory activity in this series. The search of pharmacophores was done by means of the Electronic-Topological Method (ETM). The model developed in this study is supposed to be applied to the design, preparation and screening of new compounds of similar structure in order to further test and optimize the model with the eventual goal of preparing new anti-tubercular agents. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | DRUGS OF THE FUTURE |
| Dergi ISSN | 0377-8282 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 07-2007 |
| Cilt No | 32 |
| Sayı | 11 |
| Sayfalar | 123 / 124 |
| Doi Numarası | 10.1016/j.ejmech.2006.06.009 |
| Makale Linki | http://linkinghub.elsevier.com/retrieve/pii/S0223523406002339 |
| Atıf Sayıları | |
| Google Scholar | 371 |
