Investigation of structure activity relationship on 17 spirolactone derivatives the electronic topological approach
Yazarlar (4)
Prof. Dr. Fatma Kandemirli Kocaeli Üniversitesi, Türkiye
Nesrin Tokay
Kocaeli Üniversitesi, Türkiye
Kocaeli Üniversitesi, Türkiye
Nataly M. Shvets
Kocaeli Üniversitesi, Türkiye
Kocaeli Üniversitesi, Türkiye
Anatoly S. Dimoglo
Kocaeli Üniversitesi, Türkiye
Kocaeli Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | FARMACO | ||
| Dergi ISSN | 0014-827X | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2002 |
| Cilt / Sayı / Sayfa | 57 / 7 / 601–607 | DOI | 10.1016/S0014-827X(02)01256-9 |
| UAK Araştırma Alanları |
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| Özet |
| Sixty steroid homologues belonging to a series of 17-spirolactone derivatives such as aldosterone antagonists were investigated by electronic-topological method (ETM). Activity features Ph1–Ph3 that also are called pharmacophores were revealed. The pharmacophore Ph1 consists of two oxygen atoms and four carbon atoms. The mineralocorticoid activity appeared to be affected by the distance between the two oxygen atoms. Features AP1–AP3 that are characteristic of inactive compounds (or anti-pharmacophores) were also revealed. Comparative analysis of molecules that include either pharmacophores or anti-pharmacophores was carried out. |
| Anahtar Kelimeler |
| Aldosterone | Electronic-topological method | Mineralocorticoids |
Science Direct
Investigation of structure activity relationship on 17 spirolactone derivatives the electronic topological approach
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Google Scholar | 9 |