| Yazarlar |
Prof. Dr. Fatma KANDEMİRLİ
Kocaeli Üniversitesi, Türkiye |
Murat Saraçoğlu
Erciyes Üniversitesi, Türkiye |
|
V Kovalishyn
|
| Özet |
| The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. Molecular fragments specific for active compounds and breaks of activity were calculated for human AChE by applying the ETM and Neural Network methods. Requirements necessary for a compound to be active were formulated; they are the result of detailed analysis of all compounds under study. A comparative study of the activity features found for human AChE was performed. © 2005 Bentham Science Publishers Ltd. |
| Anahtar Kelimeler |
| human AChE inhibitors,electronic topological method,neural network method |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Mini-Reviews in Medicinal Chemistry |
| Dergi ISSN | 1389-5575 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 05-2005 |
| Cilt No | 5 |
| Sayı | 5 |
| Sayfalar | 479 / 487 |
| Doi Numarası | 10.2174/1389557053765529 |
| Makale Linki | http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-5575&volume=5&issue=5&spage=479 |
| Atıf Sayıları | |
| WoS | 11 |
| SCOPUS | 13 |
