1 3 4 Thiadiazole Derivatives Synthesis Structure Elucidation and Structure Antituberculosis Activity Relationship Investigation
Yazarlar (5)
Elçin E. Oruç Marmara Üniversitesi, Türkiye
Sevim Rollas
Marmara Üniversitesi, Türkiye
Marmara Üniversitesi, Türkiye
Prof. Dr. Fatma Kandemirli Kocaeli Üniversitesi, Türkiye
Nathaly Shvets Institute Of Technology, Türkiye
Anatholy S. Dimoglo Institute Of Technology, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Medicinal Chemistry (Q1) | ||
| Dergi ISSN | 0022-2623 Dergi Bilgileri (2004) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2004 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-12-2004 |
| Cilt / Sayı / Sayfa | 47 / 27 / 6760–6767 | DOI | 10.1021/jm0495632 |
| Makale Linki | http://pubs.acs.org/doi/abs/10.1021/jm0495632 | ||
| UAK Araştırma Alanları |
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| Özet |
| A series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized, the compounds structures were elucidated and screened for the antituberculosis activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system. Among the tested compounds, 2-phenylamino-5-(4-fluorophenyl)-1,3,4-thiadiazole 22 showed the highest inhibitory activity. The relationships between the structures of compounds and their antituberculosis activity were investigated by the Electronic−Topological Method (ETM) and feed forward neural networks (FFNNs) trained with the back-propagation algorithm. As a result of the approach, a system of pharmacophores and anti-pharmacophores has been found that effectively separates compounds of the examination set into groups of active and inactive compounds. The system can be applied to the screening and design of new active compounds possessing skeletons … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 232 |
| Scopus | 27 |
| Google Scholar | 379 |