Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration
Yazarlar (6)
Doç. Dr. Ertuğrul TERZİ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Orhan Çorum Kastamonu Üniversitesi, Türkiye
Doç. Dr. Soner BİLEN Kastamonu Üniversitesi, Türkiye
Arş. Gör. Dr. Osman Nezih KENANOĞLU Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Orkun Atik Afyon Kocatepe Üniversitesi, Türkiye
Prof. Dr. Kamil Üney Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Aquaculture (Q1) | ||
| Dergi ISSN | 0044-8486 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2020 |
| Cilt / Sayı / Sayfa | 520 / 1 / 734984–0 | DOI | 10.1016/j.aquaculture.2020.734984 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0044848619316333 | ||
| UAK Araştırma Alanları |
Su Ürünleri
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| Özet |
| The pharmacokinetics of danofloxacin was studied in rainbow trout (Oncorhynchus mykiss) after single administration by intravenous (IV), intramuscular (IM) and oral (OR) gavage at a dose of 10 mg/kg and by 10 mg/L bath for 2 h at 11.7 ± 0.8 °C. Furthermore, minimal inhibitory concentrations (MICs) of danofloxacin against a pathogenic strain of Yersinia ruckeri, Pseudomonas spp., and Aeromonas hydrophila were determined. Plasma concentrations of danofloxacin were determined using high-performance liquid chromatograph - UV and further subjected to noncompartmental analysis. Elimination half-lives for IV, IM, OR and bath administration were 25.97 h, 42.43 h, 41.04 h and 40.41 h, respectively. Peak plasma concentrations (Cmax) for IM, OR and bath administration were 3.64 ± 0.12, 2.93 ± 0.23, and 0.36 ± 0.02 μg/mL, respectively. Bioavailability was 105.87% (IM), 96.92% (OR) and 10.09% (bath). MIC … |
| Anahtar Kelimeler |
| Danofloxacin | Pharmacodynamics | Pharmacokinetics | Rainbow trout |
Science Direct
Pharmacokinetics of danofloxacin in rainbow trout after different routes of administration
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 39 |
| Google Scholar | 48 |