| Yazarlar |
Ümit Acar
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Yavuz Erden
Bartın Üniversitesi, Türkiye |
|
Burak Evren İnanan
Aksaray Üniversitesi, Türkiye |
Doç. Dr. Osman Sabri KESBİÇ
Kastamonu Üniversitesi, Türkiye |
|
Sevdan Yılmaz
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
|
Ekrem Şanver Çelik
Çanakkale Onsekiz Mart Üniversitesi, Türkiye |
| Özet |
| Among pesticides, fungicides are the most extensively used ones in agriculture and their effects on fish health and indirectly human health are needed to evaluate. Folpet has been used for over 50 years as a fungicide across the world. The mechanism of action of folpet on non-target aquatic organisms is so poorly understood and there is no available information about potential acute toxicity of folpet and its mechanism of action in non-target aquatic organisms. With this motivation, two successive experiments were set up: first, 96 h-LC50 value of folpet for common carp (Cyprinus carpio) was determined; and second, effects of different sublethal concentrations (0, 0.025, 0.50, 0.1 and 0.15 mg/L) of folpet on hematological serum biochemical blood parameters, DNA damages, expression levels of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione S-transferase (GST), and cortisol receptor (HSP70) genes were evaluated in this study. It was calculated that 0.199 mg/L of folpet was the 96 h-LC50 value. After the folpet exposure for 14 days, significant decreases in red blood cells, hemoglobin, hematocrit, serum total protein, and GST gene expression levels were observed while serum glucose, liver enzymes activities, and expression levels of CAT, SOD, GPx, HSP70 genes increased. Also, folpet induced a significant genotoxic effect on the blood cells regarding to DNA damages. Consequently, the results have shown the toxic effects of folpet even at the lowest concentration on common carp. |
| Anahtar Kelimeler |
| Folpet,Genotoxicity,Comet assay,Gene expression,Cyprinus carpio |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology |
| Dergi ISSN | 1532-0456 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2023 |
| Cilt No | 263 |
| Sayfalar | 109494 / |
| Doi Numarası | 10.1016/j.cbpc.2022.109494 |
| Makale Linki | http://dx.doi.org/10.1016/j.cbpc.2022.109494 |
| Atıf Sayıları | |
| WoS | 5 |
| SCOPUS | 5 |
| Google Scholar | 4 |
