| Yazarlar |
Dr. Öğr. Üyesi Çiğdem SEVİM
Türkiye |
Erol Akpınar
Türkiye |
Doç. Dr. Emrah Hicazi AKSU
Kastamonu Üniversitesi, Türkiye |
|
Ali Doğan Ömür
Türkiye |
|
Serkan Yıldırım
Atatürk Üniversitesi, Türkiye |
|
Mehtap Kara
Türkiye |
|
İsmail Bolat
Türkiye |
|
Aristides Tsatsakis
|
|
Robin Mesnage
|
|
Kirill S. Golokhvast
|
|
Sevgi Karabulut Uzunçakmak
Türkiye |
|
Rabia Nilüfer Ersoylu
|
| Özet |
| The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system. |
| Anahtar Kelimeler |
| Saccharomyces boulardii | acetamiprid | imidacloprid | probiotic |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TOXICS |
| Dergi ISSN | 2305-6304 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2023 |
| Cilt No | 11 |
| Sayı | 2 |
| Doi Numarası | 10.3390/toxics11020170 |
| Makale Linki | http://dx.doi.org/10.3390/toxics11020170 |
| Atıf Sayıları | |
| WoS | 6 |
| SCOPUS | 6 |
