| Yazarlar |
Fatih Mehmet Kandemir
Türkiye |
|
Cüneyt Çağlayan
Türkiye |
Doç. Dr. Emrah Hicazi AKSU
Türkiye |
|
Serkan Yıldırım
Atatürk Üniversitesi, Türkiye |
|
Sefa Küçükler
Türkiye |
|
Cihan Gür
Türkiye |
|
Gizem Eser
Türkiye |
| Özet |
| This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl2) group received 1.23 mg/kg/b.w. of HgCl2 for 7 days. Mercury chloride + rutin-50 group received 50 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. HgCl2 + rutin-100 group received 100 mg/kg/b.w. rutin and HgCl2 1.23 mg/kg/b.w. for 7 days. It was detected that HgCl2 treatment increased malondialdehyde (MDA) levels, tumour necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) expressions, necrosis and degeneration of spermatogonium, dead and abnormal sperm percentages; tubular walls thinning; and decreased antioxidant enzyme activities and sperm motility. It was determined that rutin application reduced testicular damage caused by HgCl2. In conclusion, rutin administration may treat HgCl2 toxicity in testes. |
| Anahtar Kelimeler |
| inflammation | mercuric chloride | oxidative stress | reproductive toxicity | rutin |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ANDROLOGIA |
| Dergi ISSN | 0303-4569 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2020 |
| Cilt No | 52 |
| Sayı | 3 |
| Doi Numarası | 10.1111/and.13524 |
| Atıf Sayıları | |
| WoS | 49 |
| SCOPUS | 55 |
