The antiapoptotic and antioxidant effects of eugenol against cisplatin‐induced testicular damage in the experimental model
Yazarlar (8)
Akdemir Fazile Ekinci
Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye
Prof. Dr. Fatih Mehmet Kandemir Atatürk Üniversitesi, Türkiye
Prof. Dr. Emrah Hicazi Aksu Atatürk Üniversitesi, Türkiye
Mustafa C Guler
Ozmen Hilal Kiziltunc
Doç. Dr. Sefa Küçükler Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gizem Eser Iğdır Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ANDROLOGIA (Q3) | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2019 |
| Cilt / Sayı / Sayfa | 51 / 9 / – | DOI | 10.1111/and.13353 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1111/and.13353 | ||
| UAK Araştırma Alanları |
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| Özet |
| Testicular dysfunction or damage is among the critical side effects of chemotherapeutic drugs like cisplatin. This study was mapped out to assess the possible therapeutic effect of eugenol on cisplatin-induced testicular damage. In this experimental study, a single dose of cisplatin (15 mg/kg) was given intraperitoneally. After 72 hr of cisplatin injection, rats were sacrificed and testis tissues were removed. Tissues were examined by biochemical, histopathological and immunohistochemical methods. While tissue lipid peroxidation product and apoptotic marker levels increased, antioxidant enzyme activities of testis tissue were decreased in the cisplatin group. Additionally, histopathological damage was also determined in testis tissue. Contrary to all these results, the severity of damage in the tissue was reduced histopathologically owing to eugenol treatment. The lipid peroxidation decreased and antioxidant enzyme activities increased in the eugenol treatment group. It has been determined that eugenol has a therapeutic effect on oxidative stress and apoptosis against cisplatin-induced testicular damage. |
| Anahtar Kelimeler |
| cisplatin | eugenol | testis | toxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |