Palliative effect of curcumin on doxorubicin‐induced testicular damage in male rats
Yazarlar (7)
Prof. Dr. Emrah Hicazi Aksu Atatürk Üniversitesi, Türkiye
Fatih Mehmet Kandemir Atatürk Üniversitesi, Türkiye
Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye
Sefa Küçükler Atatürk Üniversitesi, Türkiye
Doç. Dr. Muhammed Yaşar Dörtbudak Harran Üniversitesi, Türkiye
Cüneyt Çağlayan Bingöl Üniversitesi, Türkiye
Prof. Dr. Fulya Benzer Munzur Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (Q1) | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2019 |
| Cilt / Sayı / Sayfa | 33 / 10 / – | DOI | 10.1002/jbt.22384 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22384 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity. |
| Anahtar Kelimeler |
| curcumin | DNA damage | doxorubicin | oxidative stress | testicular toxicity |
BM Sürdürülebilir Kalkınma Amaçları
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