Improvement in colistin-induced reproductive damage, apoptosis, and autophagy in testes via reducing oxidative stress by chrysin
Yazarlar (4)
Prof. Dr. Emrah Hicazi Aksu Atatürk Üniversitesi, Türkiye
Prof. Dr. Fatih Mehmet Kandemir Atatürk Üniversitesi, Türkiye
Doç. Dr. Sefa Küçükler Atatürk Üniversitesi, Türkiye
Amdia Mahamadu
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (Q2) | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2018 |
| Cilt / Sayı / Sayfa | 32 / 11 / 22201–0 | DOI | 10.1002/jbt.22201 |
| Makale Linki | http://doi.wiley.com/10.1002/jbt.22201 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
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| Özet |
| This study aimed to investigate the effect of chrysin on colistin-induced reproductive toxicity. Twenty-eight adult male Sprague-Dawley rats were divided into four groups of seven rats each. Group I received physiological saline for 7 days. Group II received 50 mg/kg/day chrysin for 7 days. Group III received a total dose of 73 mg/kg colistin for 7 days. Group IV received 50 mg/kg/day chrysin by an oral gavage after the colistin treatment. Colistin causes an increase in oxidative stress (OS) in the testis. Chrysin treatment significantly decreased the OS in the chrysin + colistin group compared with the colistin group. The highest caspase-3 and LC3B expression levels were found in the colistin group and these levels were statistically lower in the chrysin + colistin group. Colistin treatment caused a decrease in sperm motility and an increase in sperm abnormality. Chrysin treatment mitigated these side effects significantly. In conclusion, chrysin treatment can be beneficial against colistin-induced reproductive toxicity. |
| Anahtar Kelimeler |
| apoptosis | autophagy | colistin | oxidative stress | reproductive toxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |