| Yazarlar |
Doç. Dr. Emrah Hicazi AKSU
Atatürk Üniversitesi, Türkiye |
Fatih Mehmet Kandemir
Atatürk Üniversitesi, Türkiye |
|
Sefa Küçükler
Atatürk Üniversitesi, Türkiye |
|
Amdia Mahamadu
|
| Özet |
| This study aimed to investigate the effect of chrysin on colistin-induced reproductive toxicity. Twenty-eight adult male Sprague-Dawley rats were divided into four groups of seven rats each. Group I received physiological saline for 7 days. Group II received 50 mg/kg/day chrysin for 7 days. Group III received a total dose of 73 mg/kg colistin for 7 days. Group IV received 50 mg/kg/day chrysin by an oral gavage after the colistin treatment. Colistin causes an increase in oxidative stress (OS) in the testis. Chrysin treatment significantly decreased the OS in the chrysin + colistin group compared with the colistin group. The highest caspase-3 and LC3B expression levels were found in the colistin group and these levels were statistically lower in the chrysin + colistin group. Colistin treatment caused a decrease in sperm motility and an increase in sperm abnormality. Chrysin treatment mitigated these side effects significantly. In conclusion, chrysin treatment can be beneficial against colistin-induced reproductive toxicity. |
| Anahtar Kelimeler |
| apoptosis | autophagy | colistin | oxidative stress | reproductive toxicity |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY |
| Dergi ISSN | 1095-6670 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2018 |
| Cilt No | 32 |
| Sayı | 11 |
| Sayfalar | 22201 / 0 |
| Doi Numarası | 10.1002/jbt.22201 |
| Makale Linki | http://doi.wiley.com/10.1002/jbt.22201 |
| Atıf Sayıları | |
| WoS | 28 |
| SCOPUS | 32 |
