3 3 diindolylmethane leads to apoptosis decreases sperm quality affects blood estradiol 17 and testosterone oestrogen and and androgen receptor levels in the reproductive system in male rats
Yazarlar (8)
Prof. Dr. Emrah Hicazi Aksu Atatürk Üniversitesi, Türkiye
Orhan Akman
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Prof. Dr. Ali Doğan Ömür Atatürk Üniversitesi, Türkiye
Emre Karakuş
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
İsmail Can Kafkas Üniversitesi, Türkiye
Prof. Dr. Fatih Mehmet Kandemir Atatürk Üniversitesi, Türkiye
Emrullah Dorman
Ömer Uçar Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | ANDROLOGIA | ||
| Dergi ISSN | 0303-4569 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2016 |
| Cilt / Sayı / Sayfa | 48 / 10 / 1155–1165 | DOI | 10.1111/and.12554 |
| Makale Linki | http://doi.wiley.com/10.1111/and.12554 | ||
| UAK Araştırma Alanları |
Dölerme ve Suni Tohumlama
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| Özet |
| 3,3 Diindolylmethane (DIM) is a major digestive product of indole-3 carbinol, obtained from Brassica family vegetables such as broccoli, cabbage and Brussels sprouts. This study aimed to investigate the effects of DIM on sperm parameters, histological structures of testicular tissues, blood testosterone (T) and estradiol 17-β (E2) in male rats. Thirty-eight male Sprague Dawley rats were used. Rats were divided into four groups: Group I: referred as Control group, received corn oil only; Group II: as DIM-10, rats received 10 mg kg−1 DIM; Group III: as DIM-50, rats received 50 mg kg−1 DIM; Group IV: as DIM-100, received 100 mg kg−1 DIM during 53 days. Spermatological parameters, malondialdehyde (MDA) levels of testes and serum T and E2 levels were assayed. Histopathological examinations of tests were done. DIM caused an increase in MDA levels. It decreased motility and live sperm rates and increased degeneration of testicular tissues. While DIM-10 did not affect abnormal sperm rate, higher concentrations increased the abnormalities. Sperm density was higher in DIM-10 groups when compared to both other groups. Only DIM-50 had an anti-androgenic effect among all groups. Only, DIM-10 showed anti-estrogenic activity as compared to higher DIM groups. In conclusion, DIM (i) had side effect on some sperm characteristics, (ii) increased the MDA levels and (iii) led to histological degeneration of testicular tissues and apoptosis in a dose-dependent manner. |
| Anahtar Kelimeler |
| Androgen receptors | apoptosis | diindolylmethane | male reproductive system | rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |