Ameliorative Effect of Carvacrol on Cisplatin Induced Reproductive Damage in Male Rats
Yazarlar (6)
Prof. Dr. Emrah Hicazi Aksu Atatürk Üniversitesi, Türkiye
Prof. Dr. Fatih Mehmet Kandemir Atatürk Üniversitesi, Türkiye
Prof. Dr. Serdar Altun Atatürk Üniversitesi, Türkiye
Sefa Küçükler
Doç. Dr. Selim Çomaklı Atatürk Üniversitesi, Türkiye
Prof. Dr. Ali Doğan Ömür Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2016 |
| Cilt / Sayı / Sayfa | 30 / 10 / 513–520 | DOI | 10.1002/jbt.21816 |
| Makale Linki | http://doi.wiley.com/10.1002/jbt.21816 | ||
| UAK Araştırma Alanları |
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| Özet |
| Cisplatin (CP) treatment causes the damage in male reproductive system. Carvacrol (CARV) is an antioxidant that is naturally found in some plants. We aimed to investigate the effect of CARV on CP-induced reproductive toxicity in male rats. Eighteen adult male Sprague–Dawley rats were used. The control group (n = 6) was treated orally with physiological saline (PS) daily for 14 days and a single intraperitoneal (IP) PS injection on day 10. The CP group (n = 6) was administered with daily oral PS for 14 days and a single IP injection of 10 mg/kg CP on day 10. The CARV + CP group (n = 6) was treated with daily 75 mg/kg oral CARV for 14 days and a single IP injection of 10 mg/kg CP on day 10. CP treatment caused the damage on some spermatological parameters (motility, live sperm rate, and abnormal sperm rate), increased the oxidative stress, and induced testicular degeneration and apoptosis. However, CARV treatment mitigates CP-induced reproductive toxicity. |
| Anahtar Kelimeler |
| Apoptosis | Carvacrol | Cisplatin | Oxidative Stress | Spermiotoxicity |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |