Paraoxonase and Arylesterase Activities in Dipper and Non Dipper Prehypertensive Subjects
Yazarlar (8)
Murat Yuksel Cardiology Department, Amerika Birleşik Devletleri
Prof. Dr. Abdulkadir YILDIZ Cardiology Department, Amerika Birleşik Devletleri
Ebru Tekbas Cardiology Department, Amerika Birleşik Devletleri
Ercan Gunduz Internal Medicine/Division Of Emergency, Türkiye
Aysun Ekinci Dicle University, Faculty Of Medicine, Türkiye
Mehmet Zihni Bilik Cardiology Department, Amerika Birleşik Devletleri
Necdet Ozaydogdu Cardiology Department, Amerika Birleşik Devletleri
Zuhal Atilgan Cardiology Department, Amerika Birleşik Devletleri
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Medicine United States | ||
| Dergi ISSN | 0025-7974 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2015 |
| Cilt / Sayı / Sayfa | 94 / 17 / – | DOI | 10.1097/MD.0000000000000786 |
| Makale Linki | http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpagean=00005792-201505010-00034 | ||
| Özet |
| Paraoxonase-1, a high-density lipoprotein linked enzyme complex, was shown to be decreased in several cardiovascular diseases. We aimed to explore whether serum paraoxonase and arylesterase activities differ in dipper and non-dipper prehypertensive subjects compared to healthy controls. Sixty prehypertensive subjects and 30 controls were enrolled. All subjects underwent echocardiographic assessment and 24-hour ambulatory blood pressure monitoring (ABPM). According to the blood pressure (BP) course on ABPM, prehypertensive subjects were categorized into two: non-dipper prehypertensive (NDPH) and dipper prehypertensive (DPH) groups. Serum paraoxonase and arylesterase activities were detected spectrophotometrically. Paraoxonase and arylesterase activities were significantly lower in patients with NDPH compared to both DPH and control groups. Both paraoxonase and arylesterase activities showed significant negative correlations with BP and left ventricular mass index. We have demonstrated that NDPH subjects have lower paraoxonase and arylesterase activities compared to DPH subjects and normotensives. Further prospective studies are needed to clarify the role of paraoxonase and arylesterase activities in the development of overt hypertension in prehypertensive subjects. |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |