The protective role of glutamine against acute induced toxicity in rats
Yazarlar (10)
Prof. Dr. Mesut Aydin Dicle University, Faculty Of Medicine, Türkiye
Prof. Dr. Abdulkadir YILDIZ Dicle University, Faculty Of Medicine, Türkiye
Ibrahim Ibiloglu Dicle University, Faculty Of Medicine, Türkiye
Aysun Ekinci Dicle University, Faculty Of Medicine, Türkiye
Burak Veli Ulger Dicle University, Faculty Of Medicine, Türkiye
Murat Yuksel Dicle University, Faculty Of Medicine, Türkiye
Prof. Dr. Mehmet Zihni Bilik Dicle University, Faculty Of Medicine, Türkiye
Necdet Ozaydogdu
Dicle University, Faculty Of Medicine, Türkiye
Dicle University, Faculty Of Medicine, Türkiye
Cenap Ekinci Dicle University, Faculty Of Medicine, Türkiye
Umit Can Yazgan Dicle University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Toxicology Mechanisms and Methods (Q3) | ||
| Dergi ISSN | 1537-6516 Dergi Bilgileri (2015) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2015 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 04-05-2015 |
| Cilt / Sayı / Sayfa | 25 / 4 / 296–301 | DOI | 10.3109/15376516.2015.1025349 |
| Makale Linki | http://www.tandfonline.com/doi/full/10.3109/15376516.2015.1025349 | ||
| UAK Araştırma Alanları |
Kardiyoloji
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| Özet |
| Context: Deltamethrin (DLM) is an insecticide commonly used to protect agricultural crops against pests. QT prolongation with malignant ventricular arrhythmias are amongst the most common cardiovascular complications. DLM intoxication cause decreased level of antioxidant enzymes. Glutamine is the precursor of glutathione which is an antioxidant and has been demonstrated to improve outcome after several critical illnesses.Objective: We hypothesized that glutamine, by means of antioxidant characteristics, may antagonize the cardiotoxic effects of DLM.Materials and methods: All experiments were performed on 8-week-old male Wistar albino rats. The rats were divided into following groups (n = 10); Group I: control, Group II: l-glutamine, Group III: DLM, Group IV: DLM and after 4 h l-glutamine. Total antioxidant status (TAS), total oxidant status (TOS) and parameter analyses were performed in cardiac tissue … |
| Anahtar Kelimeler |
| Amino acid | antioxidant | insecticide | oxidant |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 13 |
| Scopus | 14 |