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Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome      
Yazarlar
Mustafa Oylumlu
Prof. Dr. Abdulkadir YILDIZ
Dicle Üniversitesi, Türkiye
Muhammed Oylumlu
Murat Yüksel
Nihat Polat
Mehmet Zihni Bilik
Abdurrahman Akyuz
Mesut Aydın
Halit Acet
Serdar Soydinc
Özet
Objective: Platelets and inflammatory cells are vital elements of acute coronary syndromes (ACS). Recent studies have shown that the plateletto- lymphocyte ratio (PLR) is associated with several malignancies; however, there are not enough data in cardiovascular diseases. Therefore, the aim of this study was to explore the association between PLR and in-hospital mortality in patients with ACS. Methods: We retrospectively collected patients with ACS undergoing coronary angiography. Total and differential leukocyte counts were measured by an automated hematology analyzer. Results: This study is single-centered and observational. In total, 587 patients with a mean age of 61.8±13.1 years (68.4% male) were enrolled in the study. Patients were divided into 3 tertiles based on PLR levels. In-hospital mortality was significantly higher among patients in the upper PLR tertile when compared with the middle and lower PLR tertile groups [29 (14.8%) vs. 17 (8.7%) and 2 (1.0%); p<0.001]. In the multiple logistic regression analysis, a high level of PLR was an independent predictor of in-hospital mortality, together with age, total leukocyte count, and creatinine. Using a cutoff point of 142, the PLR predicted in-hospital mortality with a sensitivity of 69% and specificity of 63%. Conclusion: Different from other inflammatory markers and assays, PLR is an inexpensive and readily available biomarker that may be useful for cardiac risk stratification in patients with ACS.
Anahtar Kelimeler
Acute coronary syndrome | Coronary heart disease | Mortality | Platelet-to-lymphocyte ratio
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı ANATOLIAN JOURNAL OF CARDIOLOGY
Dergi ISSN 2149-2263
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 04-2015
Cilt No 15
Sayı 4
Sayfalar 277 / 283
Doi Numarası 10.5152/akd.2014.5366
Makale Linki https://www.journalagent.com/anatoljcardiol/pdfs/AnatolJCardiol_15_4_277_283.pdf