| Yazarlar |
Mustafa Oylumlu
|
Prof. Dr. Abdulkadir YILDIZ
Dicle Üniversitesi, Türkiye |
|
Muhammed Oylumlu
|
|
Murat Yüksel
|
|
Nihat Polat
|
|
Mehmet Zihni Bilik
|
|
Abdurrahman Akyuz
|
|
Mesut Aydın
|
|
Halit Acet
|
|
Serdar Soydinc
|
| Özet |
| Objective: Platelets and inflammatory cells are vital elements of acute coronary syndromes (ACS). Recent studies have shown that the plateletto- lymphocyte ratio (PLR) is associated with several malignancies; however, there are not enough data in cardiovascular diseases. Therefore, the aim of this study was to explore the association between PLR and in-hospital mortality in patients with ACS. Methods: We retrospectively collected patients with ACS undergoing coronary angiography. Total and differential leukocyte counts were measured by an automated hematology analyzer. Results: This study is single-centered and observational. In total, 587 patients with a mean age of 61.8±13.1 years (68.4% male) were enrolled in the study. Patients were divided into 3 tertiles based on PLR levels. In-hospital mortality was significantly higher among patients in the upper PLR tertile when compared with the middle and lower PLR tertile groups [29 (14.8%) vs. 17 (8.7%) and 2 (1.0%); p<0.001]. In the multiple logistic regression analysis, a high level of PLR was an independent predictor of in-hospital mortality, together with age, total leukocyte count, and creatinine. Using a cutoff point of 142, the PLR predicted in-hospital mortality with a sensitivity of 69% and specificity of 63%. Conclusion: Different from other inflammatory markers and assays, PLR is an inexpensive and readily available biomarker that may be useful for cardiac risk stratification in patients with ACS. |
| Anahtar Kelimeler |
| acute coronary syndrome,coronary heart disease,mortality,platelet-to-lymphocyte ratio |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology |
| Dergi ISSN | 2149-2263 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2015 |
| Cilt No | 15 |
| Sayı | 4 |
| Sayfalar | 277 / 283 |
| Doi Numarası | 10.5152/akd.2014.5366 |
| Makale Linki | https://www.journalagent.com/anatoljcardiol/pdfs/AnatolJCardiol_15_4_277_283.pdf |
| Atıf Sayıları | |
| WoS | 48 |
| SCOPUS | 54 |
| TRDizin | 14 |
