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Relation of epicardial fat thickness and brachial flow mediated vasodilation with coronary artery disease      
Yazarlar
Hasan Kaya
Faruk Ertas
Mustafa Oylumlu
Mehmet Zihni Bilik
Prof. Dr. Abdulkadir YILDIZ
Kastamonu Üniversitesi
Murat Yuksel
Nihat Polat
Halit Acet
Ferhat Isik
Mehmet Siddik Ulgen
Özet
Objective: The purpose of this study is to investigate the presence of a statistical association between epicardial fat thickness (EFT) and coronary artery disease (CAD) and between flow-mediated vasodilation (FMD) and CAD. Methods: We measured the EFT and FMD in 64 subjects with suspected stable angina pectoris. The patients were separated into two groups according to their coronary angiography results: 34 patients with CAD and 30 patients with normal coronary arteries (NCA). Results: EFT was significantly higher in the patients with CAD than the NCA group (6.43. ±. 0.90. mm vs. 5.35. ±. 0.75. mm, p<. 0.001) while FMD was significantly lower in the patients with CAD than those in the NCA group (6.41. ±. 2.51% vs. 8.33. ±. 3.45%, p= 0.015). No significant correlation was found between EFT and FMD. After adjustment for EFT, FMD, age, sex, ejection fraction, glucose, and low-density lipoprotein cholesterol through multivariate logistic regression analysis, EFT (odds ratio: 6.325, 95% confidence interval 2.289-17.476, p<. 0.001) and age (odds ratio: 1.093, 95% confidence interval 1.008-1.185, p= 0.032) remained significant predictors of CAD. A cut-off value of EFT. ≥. 5.8. mm predicted the presence of CAD with 77% sensitivity and 70% specificity. Conclusion: An echocardiographic EFT assessment is independently associated with the presence of CAD. Thus, EFT may be helpful in cardiometabolic risk stratification and therapeutic interventions. © 2013 Japanese College of Cardiology.
Anahtar Kelimeler
Coronary artery disease | Epicardial fat thickness | Flow-mediated vasodilation
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Dergi ISSN 0735-1097
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce
Basım Tarihi 10-2013
Cilt No 62
Sayı 18
Sayfalar 343 / 347
Doi Numarası 10.1016/j.jacc.2013.08.095
Makale Linki http://linkinghub.elsevier.com/retrieve/pii/S0914508713001743