Investigation of the subchronic effects of low-dose pesticide mixture on rat testes
Yazarlar (10)
Prof. Dr. Ali Doğan Ömür Atatürk Üniversitesi, Türkiye
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yavuz Selim Sağlam Atatürk Üniversitesi, Türkiye
Doç. Dr. İsmail Bolat Atatürk Üniversitesi, Türkiye
Doç. Dr. Sıdıka Genç Bilecik Şeyh Edebali Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yeşim Yeni Ataturk University, Faculty of Medicine, Türkiye
Doç. Dr. Mehmet Akif Aydın Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Serhat Sunar
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Dr. Öğr. Üyesi Gökhan Koçak Iğdır Üniversitesi, Türkiye
Doç. Dr. Serkan Ali Akarsu Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Japanese Journal of Veterinary Research (Q4) | ||
| Dergi ISSN | 0047-1917 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 71 / 3 / 82–94 | DOI | 10.57494/jjvr.71.3_82 |
| Makale Linki | https://www.jstage.jst.go.jp/article/jjvr/71/3/71_82/_article/-char/en | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| Pesticides are chemical agents used against living things such as insects, rodents, and weeds that cause toxicity in various tissues, including reproductive organs. In order to increase the effectiveness of pesticides, active ingredients are mixed with various formulations. The current study tried to determine the effects of pesticides and their mixtures on testicular tissue in rats. For this purpose, chlormequat chloride (CCC), pirimiphos methyl (PMM), glyphosate (GLY), tebuconazole (TBZ), chlorpyrifos methyl (CPM), deltamethrin (DLM), and their mix (acceptable daily intake (ADI) and ADIx10) were administried to Sprague-Dawley rats for 90 days. As a result of the examinations, the ADIx10 group showed the most damaging effect by showing a statistical difference in terms of sperm motility and membrane integrity. The GLY group had a similar effect on membrane integrity as the ADIx10 group, while it had a moderately detrimental effect on motility. Degenerations of spermatocytes, necrosis, and edema in intertubular spaces were observed in all pesticide groups. Similarly, 8-hydroxyguanosine (8-OHdG) expression and Caspase-3 expression were moderate in all pesticide groups. Moreover, 8-OHdG expression and Caspase-3 expression were higher in the ADI and ADIx10 groups compared to other groups. As a result, pesticides and their mixtures cause histopathological changes in the testicular tissue of rats and decrease sperm quality. |
| Anahtar Kelimeler |
| Oxidative stress | pesticide | rat | sperm | testis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |