Investigation of the miRNA levels changes to acceptable daily intake dose pesticide mixture exposure on rat mesentery and pancreas
Yazarlar (10)
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Arıstıdes Tsatsakıs
University of Crete, Yunanistan
Doç. Dr. Ali Taghizadehghalehjoughi Bilecik Şeyh Edebali Üniversitesi, Türkiye
Prof. Dr. Mustafa Özkaraca Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Mehtap Kara Istanbul Üniversitesi, Türkiye
Doç. Dr. Sıdıka Genç Bilecik Şeyh Edebali Üniversitesi, Türkiye
Ali Sefa Mendil
Erciyes Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yeşim Yeni Malatya Turgut Ozal University, Türkiye
Taxıarchıs Konstantınos Nıkolouzakıs
University of Crete, Yunanistan
Eren Özçağlı
Istanbul Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale)
Dergi Adı Chemosphere
Dergi ISSN 0045-6535 Dergi Bilgileri (2024)
Dergi Tarandığı Indeksler Scopus
Makale Dili İngilizce Basım Tarihi 02-2024
Kabul Tarihi Yayınlanma Tarihi 01-02-2024
Cilt / Sayı / Sayfa 349 / 1 / 1–12 DOI 10.1016/j.chemosphere.2023.140712
Makale Linki http://dx.doi.org/10.1016/j.chemosphere.2023.140712
UAK Araştırma Alanları
Tıbbi Farmakoloji
Özet
Consumers are constantly exposed to a variety of chemical mixtures as part of their everyday activities and lifestyle. Food, water and commercial products are only some examples of the possible ways people get exposed to these mixtures. However, following federal and local guidelines for risk assessment related to chemical exposure, risk analysis focuses on a single substance exposure scenario and not on a mixture, as in real life. Realizing the pronounced gap of this methodology, the real-life risk simulation scenario approach tries to address this problem by investigating the possible effect of long-term exposure to chemical mixtures closely resembling the actual circumstances of modern life. As part of this effort, this study aimed to identify the cumulative effects of pesticides belonging to different classes and commonly used commercial products on long-term exposure with realistic doses. Sprague Dawley rats …
Anahtar Kelimeler
Chlormequat | Chlorpyrifos-methyl | Deltamethrin | Glyphosate | Pirimiphos-methyl | Tebuconazole