Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

SEVİM, Çiğdem; Akpınar, Erol; Uzunçakmak, Sevgi Karabulut; Ersoylu, Rabia Nilüfer; AKSU, Emrah Hicazi; Ömür, Ali Doğan; Yıldırım, Serkan; Kara, Mehtap; Bolat, İsmail; Tsatsakıs, Arıstıdıs; Mesnage, Robın; Golokhvast, Kırıll S.

doi:10.3390/toxics11020170

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Yazarlar (12)

Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye

Erol Akpınar Atatürk Üniversitesi, Türkiye

Prof. Dr. Emrah Hicazi Aksu Kastamonu Üniversitesi, Türkiye

Ali Doğan Ömür Türkiye

Prof. Dr. Serkan Yıldırım Türkiye

Doç. Dr. Mehtap Kara Türkiye

İsmail Bolat Türkiye

Arıstıdıs Tsatsakıs

Robın Mesnage

Kırıll S. Golokhvast

Sevgi Karabulut Uzunçakmak Türkiye

Rabia Nilüfer Ersoylu

Makale Türü	Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı	TOXICS (Q1)
Dergi ISSN	2305-6304 Dergi Bilgileri (2023)
Dergi Tarandığı Indeksler	SCI-Expanded
Makale Dili	İngilizce	Basım Tarihi	02-2023
Kabul Tarihi	–	Yayınlanma Tarihi	12-02-2023
Cilt / Sayı / Sayfa	11 / 2 / 1–13	DOI	10.3390/toxics11020170
Makale Linki	http://dx.doi.org/10.3390/toxics11020170
UAK Araştırma Alanları	Tıbbi Farmakoloji

Özet

The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific evidence. In this study, we aimed to investigate the positive effects of probiotic Saccharomyces boulardii on the male reproductive system under low dose neonicotinoid pesticide exposure conditions. We observed that acetamiprid and imidacloprid caused a degeneration and necrosis of the spermatocytes in the tubular wall, a severe edema of the intertubular region and a hyperemia. This was concomittant to increased levels of 8-hydroxy-2′-deoxyguanosine reflecting oxidative stress, and an increase in caspase 3 expression, reflecting apoptosis. According to our results, Saccharomyces boulardii supplementation mitigates these toxic effects. Further in vivo and clinical studies are needed to clarify the molecular mechanisms of protection. Altogether, our study reinforces the burden of evidence from emerging studies linking the composition of the gut microbiome to the function of the reproductive system.

Anahtar Kelimeler

Saccharomyces boulardii | acetamiprid | imidacloprid | probiotic

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları
Web of Science	18

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Dergi Adı	Toxics
Kısa Adı	TOXICS
Yayıncı	MDPI
Açık Erişim	Evet
ISSN	2305-6304
E-ISSN	2305-6304
Wos Quartile	Q1
Scopus Quartile	Q1
Tarandığı Indeksler	SCIE , Scopus
WoS Kategoriler	ENVIRONMENTAL SCIENCES \| TOXICOLOGY
Scopus Kategoriler	CHEMICAL HEALTH AND SAFETY \| HEALTH, TOXICOLOGY AND MUTAGENESIS \| TOXICOLOGY

Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

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