| Yazarlar |
Dr. Öğr. Üyesi Çiğdem SEVİM
Kastamonu Üniversitesi, Türkiye |
Ali Taghizadehghalehjoughi
|
|
Mehtap Kara
İstanbul Üniversitesi, Türkiye |
| Özet |
| Background and Aims: Humans and animals have daily contact with various chemicals, including food additives, pesticides,antibiotics, other veterinary drugs, and other xenobiotics. Pesticide exposure causes many health disorders. Mixed exposure topesticides is an important issue for human and environmental health.Methods: In this study, we have determined the cytotoxicity of chlormequat pirimiphos-methyl, glyphosate, tebuconazole,chlorpyrifos-methyl, deltamethrin, and the mixture of these six pesticides. We further investigated the role of oxidativestress, total oxidant status (TOS), lactate dehydrogenase (LDH) and antioxidant defense mechanism TOS, total glutathione(GSH) levels with the observed cytotoxicity.Results: In this study, the mixtures of pesticides reduced total antioxidant status (TAS) and GSH level one by one and increased the reactive oxygen species (ROS) generation in HUVECs, respectively. The results also showed a significant contribution of oxidative stress on cytotoxicity during pesticide mixture exposure.Conclusion: The findings are that pesticide mixture exposure might have an impact on human health risk at contaminatedsites and under occupational exposure conditions. |
| Anahtar Kelimeler |
| Chlorpyrifos-methyl,chlormequat,deltamethrin,glyphosate,pirimiphos-methyl,tebuconazole,oxidative stress,HUVECs |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | ISTANBUL JOURNAL OF PHARMACY |
| Dergi ISSN | 2548-0731 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2021 |
| Cilt No | 51 |
| Sayı | 2 |
| Sayfalar | 183 / 190 |
| Doi Numarası | 10.26650/IstanbulJPharm.2021.881724 |
| Makale Linki | http://dx.doi.org/10.26650/istanbuljpharm.2021.881724 |
| Atıf Sayıları | |
| WoS | 1 |
| TRDizin | 1 |
