| Yazarlar |
Murat Karameşe
Kafkas Üniversitesi, Türkiye |
|
Hakan Aydın
Atatürk Üniversitesi, Türkiye |
|
Emin Şengül
Atatürk Üniversitesi, Türkiye |
|
Volkan Gelen
Kafkas Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Çiğdem SEVİM
Atatürk Üniversitesi, Türkiye |
|
Duran Üstek
İstanbul Medipol Üniversitesi, Türkiye |
|
Emre Karakuş
Atatürk Üniversitesi, Türkiye |
| Özet |
| Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics. To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels. The rats were randomly divided into 4 groups. The first group was "Control group" and other 3 groups were probiotic application groups who received different doses of probiotics. The probiotic mixture included 12 probiotic bacteria, mostly Lactobacillus and Bifidobacterium strains. Probiotic mixture was administered to rats for 12 consecutive days. TNF-α, TGF-β, IL-1-β, IL-6, and IL-10 levels as well as serum IgG and IgA concentrations were detected in the sera after 12 days. Probiotics led to a decrease in the levels of TNF-α, IL-6 and TGF-β; however, they led to increase in the serum levels of IL-10, IgG and IgA. There were significant differences between control group and probiotic application groups (p<0.05). These data suggest that the commensal microbiota are important for stimulating both proinflammatory and regulatory responses in order to rapidly clear infections and minimize inflammation-associated tissue damage. |
| Anahtar Kelimeler |
| Bifidobacterium | Cytokines | Immunomodulation | Lactobacillus | Probiotics |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | IRANIAN JOURNAL OF IMMUNOLOGY |
| Dergi ISSN | 1735-1383 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2016 |
| Cilt No | 13 |
| Sayı | 3 |
| Sayfalar | 220 / 228 |
