| Yazarlar |
Hatice İskender
Artvin Çoruh Üniversitesi, Türkiye |
|
Güler Yenice
Atatürk Üniversitesi, Türkiye |
|
Eda Dokumacıoğlu
Artvin Çoruh Üniversitesi, Türkiye |
|
Armağan Hayırlı
Atatürk Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Çiğdem SEVİM
Atatürk Üniversitesi, Türkiye |
|
Ali Dokumacıoğlu
|
|
Kübra Asena Terim Kapakin
Atatürk Üniversitesi, Türkiye |
| Özet |
| This study was conducted to determine the effect of astaxanthin (ASX) treatment on alleviation of renal damage in high fructose induced nephrotoxicity in rats. Treatments were arranged in a 2 × 2 factorial fashion: administrations of fructose (30%, via drinking water) and ASX (1 mg/kg/day, within 0.2 ml olive oil) for 8 weeks. Data were analyzed by two-way ANOVA. The ASX treatment decreased serum urea ( < .01) and blood urea-N concentrations ( < .02) at a lower extent in rats receiving fructose than those not receiving fructose. Moreover, the ASX treatment reversed the increases in malondialdehyde (MDA) ( < .0001) and nuclear factor kappa B (NF-κB) ( < .0003) levels and the decreases in superoxide dismutase (SOD) activity ( < .0001) and sirtuin-1 (SIRT1) level ( < .0004), in the kidney upon high fructose consumption. The data suggest that ASX supplementation alleviates renal damage induced by high fructose consumption through modulating NF-κB/SIRT1 pathway and mitigating oxidative stress. |
| Anahtar Kelimeler |
| Astaxanthin | NF-κB | SIRT1 | fructose | oxidative stress |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY |
| Dergi ISSN | 1381-3455 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2020 |
| Cilt No | 126 |
| Sayı | 1 |
| Sayfalar | 89 / 93 |
| Doi Numarası | 10.1080/13813455.2018.1493609 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/13813455.2018.1493609 |
| Atıf Sayıları | |
| WoS | 15 |
